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Comparative transmissibility of SARS-CoV-2 variants Delta and Alpha in New England, USA.
Earnest, Rebecca; Uddin, Rockib; Matluk, Nicholas; Renzette, Nicholas; Turbett, Sarah E; Siddle, Katherine J; Loreth, Christine; Adams, Gordon; Tomkins-Tinch, Christopher H; Petrone, Mary E; Rothman, Jessica E; Breban, Mallery I; Koch, Robert Tobias; Billig, Kendall; Fauver, Joseph R; Vogels, Chantal B F; Bilguvar, Kaya; De Kumar, Bony; Landry, Marie L; Peaper, David R; Kelly, Kevin; Omerza, Greg; Grieser, Heather; Meak, Sim; Martha, John; Dewey, Hannah B; Kales, Susan; Berenzy, Daniel; Carpenter-Azevedo, Kristin; King, Ewa; Huard, Richard C; Novitsky, Vlad; Howison, Mark; Darpolor, Josephine; Manne, Akarsh; Kantor, Rami; Smole, Sandra C; Brown, Catherine M; Fink, Timelia; Lang, Andrew S; Gallagher, Glen R; Pitzer, Virginia E; Sabeti, Pardis C; Gabriel, Stacey; MacInnis, Bronwyn L; Tewhey, Ryan; Adams, Mark D; Park, Daniel J; Lemieux, Jacob E; Grubaugh, Nathan D.
  • Earnest R; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA. Electronic address: rebecca.earnest@yale.edu.
  • Uddin R; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Matluk N; Maine Center for Disease Control and Prevention, Augusta, ME 04333, USA; Health and Environmental Testing Laboratory, Augusta, ME 04333, USA.
  • Renzette N; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
  • Turbett SE; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Siddle KJ; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Loreth C; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Adams G; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Tomkins-Tinch CH; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Petrone ME; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.
  • Rothman JE; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.
  • Breban MI; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.
  • Koch RT; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.
  • Billig K; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.
  • Fauver JR; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.
  • Vogels CBF; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.
  • Bilguvar K; Yale Center for Genome Analysis, Yale University, New Haven, CT 06510, USA; Departments of Neurosurgery and Genetics, Yale School of Medicine, New Haven, CT 06510, USA; Department of Medical Genetics, Acibadem University School of Medicine, Istanbul, Turkey.
  • De Kumar B; Yale Center for Genome Analysis, Yale University, New Haven, CT 06510, USA.
  • Landry ML; Departments of Laboratory Medicine and Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.
  • Peaper DR; Departments of Laboratory Medicine and Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.
  • Kelly K; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
  • Omerza G; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
  • Grieser H; Maine Center for Disease Control and Prevention, Augusta, ME 04333, USA; Health and Environmental Testing Laboratory, Augusta, ME 04333, USA.
  • Meak S; Maine Center for Disease Control and Prevention, Augusta, ME 04333, USA; Health and Environmental Testing Laboratory, Augusta, ME 04333, USA.
  • Martha J; Maine Center for Disease Control and Prevention, Augusta, ME 04333, USA; Health and Environmental Testing Laboratory, Augusta, ME 04333, USA.
  • Dewey HB; The Jackson Laboratory, Bar Harbor, ME 04609, USA.
  • Kales S; The Jackson Laboratory, Bar Harbor, ME 04609, USA.
  • Berenzy D; The Jackson Laboratory, Bar Harbor, ME 04609, USA.
  • Carpenter-Azevedo K; Rhode Island Department of Health, State Health Laboratories, Providence, RI 02904, USA.
  • King E; Rhode Island Department of Health, State Health Laboratories, Providence, RI 02904, USA.
  • Huard RC; Rhode Island Department of Health, State Health Laboratories, Providence, RI 02904, USA.
  • Novitsky V; Division of Infectious Diseases, Brown University Alpert Medical School, Providence, RI 02906, USA.
  • Howison M; Research Improving People's Lives, Providence, RI 02903, USA.
  • Darpolor J; Division of Infectious Diseases, Brown University Alpert Medical School, Providence, RI 02906, USA.
  • Manne A; Division of Infectious Diseases, Brown University Alpert Medical School, Providence, RI 02906, USA.
  • Kantor R; Division of Infectious Diseases, Brown University Alpert Medical School, Providence, RI 02906, USA.
  • Smole SC; Massachusetts Department of Public Health, Boston, MA 02130, USA.
  • Brown CM; Massachusetts Department of Public Health, Boston, MA 02130, USA.
  • Fink T; Massachusetts Department of Public Health, Boston, MA 02130, USA.
  • Lang AS; Massachusetts Department of Public Health, Boston, MA 02130, USA.
  • Gallagher GR; Massachusetts Department of Public Health, Boston, MA 02130, USA.
  • Pitzer VE; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.
  • Sabeti PC; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Gabriel S; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • MacInnis BL; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Tewhey R; Department of Medical Genetics, Acibadem University School of Medicine, Istanbul, Turkey; Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA; Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME 04469, USA.
  • Adams MD; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
  • Park DJ; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Lemieux JE; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Grubaugh ND; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA; Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06510, USA. Electronic address: nathan.grubaugh@yale.edu.
Cell Rep Med ; 3(4): 100583, 2022 04 19.
Article in English | MEDLINE | ID: covidwho-1735052
ABSTRACT
The SARS-CoV-2 Delta variant rose to dominance in mid-2021, likely propelled by an estimated 40%-80% increased transmissibility over Alpha. To investigate if this ostensible difference in transmissibility is uniform across populations, we partner with public health programs from all six states in New England in the United States. We compare logistic growth rates during each variant's respective emergence period, finding that Delta emerged 1.37-2.63 times faster than Alpha (range across states). We compute variant-specific effective reproductive numbers, estimating that Delta is 63%-167% more transmissible than Alpha (range across states). Finally, we estimate that Delta infections generate on average 6.2 (95% CI 3.1-10.9) times more viral RNA copies per milliliter than Alpha infections during their respective emergence. Overall, our evidence suggests that Delta's enhanced transmissibility can be attributed to its innate ability to increase infectiousness, but its epidemiological dynamics may vary depending on underlying population attributes and sequencing data availability.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study Topics: Variants Limits: Humans Country/Region as subject: North America Language: English Journal: Cell Rep Med Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study Topics: Variants Limits: Humans Country/Region as subject: North America Language: English Journal: Cell Rep Med Year: 2022 Document Type: Article