Long-term results of hypofractionated radiotherapy in locally advanced laryngeal cancer: Single institution experience
Oral Oncology
; 118:4, 2021.
Article
in English
| EMBASE | ID: covidwho-1735116
ABSTRACT
Introduction:
Hypofractionated radiotherapy (HF-RT) has been used in the UK as a non-surgical treatment for locally advanced laryngeal cancer (LALC) in the past. HF-RT has been readopted in some departments during the COVID-19 pandemic due to having a shorter overall treatment time and fewer attendances. This study explores the outcomes of a cohort of patients treated from 2003 to 2012 at Aberdeen Royal Infirmary (Scotland, UK). Materials andMethods:
36 patients received HF-RT (55 Gy in 20 fractions) through 2D or 3D conformal radiotherapy, 7 of them received concurrent cisplatin (CRT). Overall survival (OS), locoregional recurrence free survival (LRFS), progression free survival (PFS), laryngectomy free survival (LFS), disease specific survival (DSS) and late toxicity data were analysed in patients treated with HF-RT at 1-year (1Y), 2-year (2Y) and 5-year (5Y). The same outcomes were measured between the RT and CRT group for any differences.Results:
The mean follow-up durationwas 43.0 months. OS at 1Y, 2Y and 5Y was 69.4%, 52.8% and 30.6%. LRFS at 1Y, 2Y and 5Y was 63.9%, 47.2% and 25.0%. PFS at 1Y, 2Y and 5Y was 63.9%, 44.4% and 25.0%. LFS at 1Y, 2Y and 5Y was 69.4%, 50.0% and 27.8%. DSS at 1Y, 2Y and 5Y was 63.9%, 52.8% and 30.6%. During the period of treatment and up to 5Y follow up, 41.7% of patients required an NG tube for feeding and 25% required a PEG tube at any point. 22.2% of patients required long term enteral feeding via PEG tube beyond 5Y. No significant differences were found in the survival outcomes or alternative feeding route outcomes between patients treated by RT alone or CRT.Conclusions:
HF-RT constitutes an alternative for the treatment of LALC with acceptable local control and toxicity. Further investigation is needed in the comparison of this regime with standard fractionation and its application with modern radiotherapy techniques
cisplatin; adult; advanced cancer; cancer radiotherapy; cancer recurrence; cancer surgery; cancer survival; clinical article; cohort analysis; conference abstract; conformal radiotherapy; controlled study; disease specific survival; drug therapy; enteric feeding; female; follow up; fractionation; human; hypofractionated radiotherapy; laryngectomy; larynx cancer; local recurrence free survival; male; nasogastric tube; outcome assessment; overall survival; percutaneous endoscopic gastrostomy tube; progression free survival; radiotherapy; Scotland; surgery
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
Oral Oncology
Year:
2021
Document Type:
Article
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