Photosensitized Electrospun Nanofibrous Filters for Capturing and Killing Airborne Coronaviruses under Visible Light Irradiation.
Environ Sci Technol
; 56(7): 4295-4304, 2022 04 05.
Article
in English
| MEDLINE | ID: covidwho-1735181
ABSTRACT
To address the challenge of the airborne transmission of SARS-CoV-2, photosensitized electrospun nanofibrous membranes were fabricated to effectively capture and inactivate coronavirus aerosols. With an ultrafine fiber diameter (â¼200 nm) and a small pore size (â¼1.5 µm), optimized membranes caught 99.2% of the aerosols of the murine hepatitis virus A59 (MHV-A59), a coronavirus surrogate for SARS-CoV-2. In addition, rose bengal was used as the photosensitizer for membranes because of its excellent reactivity in generating virucidal singlet oxygen, and the membranes rapidly inactivated 97.1% of MHV-A59 in virus-laden droplets only after 15 min irradiation of simulated reading light. Singlet oxygen damaged the virus genome and impaired virus binding to host cells, which elucidated the mechanism of disinfection at a molecular level. Membrane robustness was also evaluated, and in general, the performance of virus filtration and disinfection was maintained in artificial saliva and for long-term use. Only sunlight exposure photobleached membranes, reduced singlet oxygen production, and compromised the performance of virus disinfection. In summary, photosensitized electrospun nanofibrous membranes have been developed to capture and kill airborne environmental pathogens under ambient conditions, and they hold promise for broad applications as personal protective equipment and indoor air filters.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Nanofibers
/
COVID-19
Type of study:
Experimental Studies
Limits:
Animals
Language:
English
Journal:
Environ Sci Technol
Year:
2022
Document Type:
Article
Affiliation country:
Acs.est.2c00885
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