Your browser doesn't support javascript.
Combined Model of Quantitative Evaluation of Chest Computed Tomography and Laboratory Values for Assessing the Prognosis of Coronavirus Disease 2019.
Scharf, Gregor; Meiler, Stefanie; Zeman, Florian; Schaible, Jan; Poschenrieder, Florian; Knobloch, Charlotte; Kleine, Henning; Scharf, Sophie Elisabeth; Dinkel, Julien; Stroszczynski, Christian; Zorger, Niels; Hamer, Okka Wilkea.
  • Scharf G; Institut für Röntgendiagnostik, Universitätsklinikum Regensburg, Germany.
  • Meiler S; Institut für Röntgendiagnostik, Universitätsklinikum Regensburg, Germany.
  • Zeman F; Zentrum für Klinische Studien, Universitätsklinikum Regensburg, Germany.
  • Schaible J; Institut für Röntgendiagnostik, Universitätsklinikum Regensburg, Germany.
  • Poschenrieder F; Institut für Röntgendiagnostik, Universitätsklinikum Regensburg, Germany.
  • Knobloch C; Institut für Röntgendiagnostik, Universitätsklinikum Regensburg, Germany.
  • Kleine H; Klinik für Pneumologie, Krankenhaus Barmherzige Brüder Regensburg, Germany.
  • Scharf SE; Fakultät für Sozialwissenschaften, Universität Mannheim, Germany.
  • Dinkel J; Klinik und Poliklinik für Radiologie, Klinikum der Universität München, Germany.
  • Stroszczynski C; Abteilung für Radiologie, Asklepios Fachkliniken München-Gauting, Germany.
  • Zorger N; Institut für Röntgendiagnostik, Universitätsklinikum Regensburg, Germany.
  • Hamer OW; Institut für Radiologie, Krankenhaus Barmherzige Brüder Regensburg, Germany.
Rofo ; 194(7): 737-746, 2022 07.
Article in English | MEDLINE | ID: covidwho-1735321
ABSTRACT

PURPOSE:

To assess the prognostic power of quantitative analysis of chest CT, laboratory values, and their combination in COVID-19 pneumonia. MATERIALS AND

METHODS:

Retrospective analysis of patients with PCR-confirmed COVID-19 pneumonia and chest CT performed between March 07 and November 13, 2020. Volume and percentage (PO) of lung opacifications and mean HU of the whole lung were quantified using prototype software. 13 laboratory values were collected. Negative outcome was defined as death, ICU admittance, mechanical ventilation, or extracorporeal membrane oxygenation. Positive outcome was defined as care in the regular ward or discharge. Logistic regression was performed to evaluate the prognostic value of CT parameters and laboratory values. Independent predictors were combined to establish a scoring system for prediction of prognosis. This score was validated on a separate validation cohort.

RESULTS:

89 patients were included for model development between March 07 and April 27, 2020 (mean age 60.3 years). 38 patients experienced a negative outcome. In univariate regression analysis, all quantitative CT parameters as well as C-reactive protein (CRP), relative lymphocyte count (RLC), troponin, and LDH were associated with a negative outcome. In a multivariate regression analysis, PO, CRP, and RLC were independent predictors of a negative outcome. Combination of these three values showed a strong predictive value with a C-index of 0.87. A scoring system was established which categorized patients into 4 groups with a risk of 7 %, 30 %, 67 %, or 100 % for a negative outcome. The validation cohort consisted of 28 patients between May 5 and November 13, 2020. A negative outcome occurred in 6 % of patients with a score of 0, 50 % with a score of 1, and 100 % with a score of 2 or 3.

CONCLUSION:

The combination of PO, CRP, and RLC showed a high predictive value for a negative outcome. A 4-point scoring system based on these findings allows easy risk stratification in the clinical routine and performed exceptionally in the validation cohort. KEY POINTS · A high PO is associated with an unfavorable outcome in COVID-19. · PO, CRP, and RLC are independent predictors of an unfavorable outcome, and their combination has strong predictive power. · A 4-point scoring system based on these values allows quick risk stratification in a clinical setting. CITATION FORMAT · Scharf G, Meiler S, Zeman F et al. Combined Model of Quantitative Evaluation of Chest Computed Tomography and Laboratory Values for Assessing the Prognosis of Coronavirus Disease 2019. Fortschr Röntgenstr 2022; 194 737 - 746.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans / Middle aged Language: English Journal: Rofo Year: 2022 Document Type: Article Affiliation country: A-1731-7905

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans / Middle aged Language: English Journal: Rofo Year: 2022 Document Type: Article Affiliation country: A-1731-7905