Your browser doesn't support javascript.
SARS-CoV-2 reinfection and COVID-19 severity.
Nguyen, Nhu Ngoc; Houhamdi, Linda; Hoang, Van Thuan; Delerce, Jeremy; Delorme, Léa; Colson, Philippe; Brouqui, Philippe; Fournier, Pierre-Edouard; Raoult, Didier; Gautret, Philippe.
  • Nguyen NN; IRD, AP-HM, SSA, VITROME, Aix Marseille University, Marseille, France.
  • Houhamdi L; IHU-Méditerranée Infection, Marseille, France.
  • Hoang VT; IRD, AP-HM, SSA, VITROME, Aix Marseille University, Marseille, France.
  • Delerce J; IHU-Méditerranée Infection, Marseille, France.
  • Delorme L; Thai Binh University of Medicine and Pharmacy, Thai Binh, Vietnam.
  • Colson P; IHU-Méditerranée Infection, Marseille, France.
  • Brouqui P; IRD, AP-HM, MEPHI, Aix-Marseille University, Marseille, France.
  • Fournier PE; IRD, AP-HM, SSA, VITROME, Aix Marseille University, Marseille, France.
  • Raoult D; IHU-Méditerranée Infection, Marseille, France.
  • Gautret P; IHU-Méditerranée Infection, Marseille, France.
Emerg Microbes Infect ; 11(1): 894-901, 2022 12.
Article in English | MEDLINE | ID: covidwho-1735490
ABSTRACT
SARS-CoV-2 reinfection rate is low. The relative severity of the first and second episodes of infection remains poorly studied. In this study, we aimed at assessing the frequency of SARS-CoV-2 reinfections and comparing the severity of the first and second episodes of infection. We retrospectively included patients with SARS-CoV-2 positive RT-PCR at least 90 days after clinical recovery from a COVID-19 episode and with at least one negative RT-PCR after the first infection. Whole genome sequencing and variant-specific RT-PCR were performed and clinical symptoms and severity of infection were retrospectively documented from medical files. A total of 209 COVID-19 reinfected patients were identified, accounting for 0.4% of positive cases diagnosed from 19 March 2020 to 24 August 2021. Serology was performed in 64 patients, of whom 39 (60.1%) had antibodies against SARS-CoV-2 when sampled at the early stage of their second infection. Only seven patients (3.4%) were infected twice with the same variant. We observed no differences in clinical presentation, hospitalization rate, and transfer to ICU when comparing the two episodes of infections. Our results suggest that the severity of the second episode of COVID-19 is in the same range as that of the first infection, including patients with antibodies.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study Topics: Variants Limits: Humans Language: English Journal: Emerg Microbes Infect Year: 2022 Document Type: Article Affiliation country: 22221751.2022.2052358

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study Topics: Variants Limits: Humans Language: English Journal: Emerg Microbes Infect Year: 2022 Document Type: Article Affiliation country: 22221751.2022.2052358