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Interconnection of periodontal disease and comorbidities: Evidence, mechanisms, and implications.
Hajishengallis, George.
  • Hajishengallis G; Department of Basic and Translational Sciences, Penn Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Periodontol 2000 ; 89(1): 9-18, 2022 06.
Article in English | MEDLINE | ID: covidwho-1735976
ABSTRACT
Periodontitis, a microbiome-driven inflammatory disease of the tooth-attachment apparatus, is epidemiologically linked with other disorders, including cardio-metabolic, cognitive neurodegenerative and autoimmune diseases, respiratory infections, and certain cancers. These associations may, in part, be causal, as suggested by interventional studies showing that local treatment of periodontitis reduces systemic inflammation and surrogate markers of comorbid diseases. The potential cause-and-effect connection between periodontitis and comorbidities is corroborated by studies in preclinical models of disease, which additionally provided mechanistic insights into these associations. This overview discusses recent advances in our understanding of the periodontitis-systemic disease connection, which may potentially lead to innovative therapeutic options to reduce the risk of periodontitis-linked comorbidities.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Periodontal Diseases / Periodontitis / Microbiota Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Periodontol 2000 Journal subject: Dentistry Year: 2022 Document Type: Article Affiliation country: Prd.12430

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Periodontal Diseases / Periodontitis / Microbiota Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Periodontol 2000 Journal subject: Dentistry Year: 2022 Document Type: Article Affiliation country: Prd.12430