Interconnection of periodontal disease and comorbidities: Evidence, mechanisms, and implications.
Periodontol 2000
; 89(1): 9-18, 2022 06.
Article
in English
| MEDLINE | ID: covidwho-1735976
ABSTRACT
Periodontitis, a microbiome-driven inflammatory disease of the tooth-attachment apparatus, is epidemiologically linked with other disorders, including cardio-metabolic, cognitive neurodegenerative and autoimmune diseases, respiratory infections, and certain cancers. These associations may, in part, be causal, as suggested by interventional studies showing that local treatment of periodontitis reduces systemic inflammation and surrogate markers of comorbid diseases. The potential cause-and-effect connection between periodontitis and comorbidities is corroborated by studies in preclinical models of disease, which additionally provided mechanistic insights into these associations. This overview discusses recent advances in our understanding of the periodontitis-systemic disease connection, which may potentially lead to innovative therapeutic options to reduce the risk of periodontitis-linked comorbidities.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Periodontal Diseases
/
Periodontitis
/
Microbiota
Type of study:
Observational study
/
Prognostic study
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
Periodontol 2000
Journal subject:
Dentistry
Year:
2022
Document Type:
Article
Affiliation country:
Prd.12430
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