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Cardiovascular disturbances in COVID-19: an updated review of the pathophysiology and clinical evidence of cardiovascular damage induced by SARS-CoV-2.
Lawal, Ismaheel O; Kgatle, Mankgopo M; Mokoala, Kgomotso; Farate, Abubakar; Sathekge, Mike M.
  • Lawal IO; Department of Nuclear Medicine, University of Pretoria, Pretoria, 0001, South Africa. ismaheellawal@gmail.com.
  • Kgatle MM; Nuclear Medicine Research Infrastructure, Steve Biko Academic Hospital, Pretoria, South Africa. ismaheellawal@gmail.com.
  • Mokoala K; Department of Nuclear Medicine, University of Pretoria, Pretoria, 0001, South Africa.
  • Farate A; Nuclear Medicine Research Infrastructure, Steve Biko Academic Hospital, Pretoria, South Africa.
  • Sathekge MM; Department of Nuclear Medicine, University of Pretoria, Pretoria, 0001, South Africa.
BMC Cardiovasc Disord ; 22(1): 93, 2022 03 09.
Article in English | MEDLINE | ID: covidwho-1736340
ABSTRACT
Severe acute respiratory coronavirus-2 (SARS-Co-2) is the causative agent of coronavirus disease-2019 (COVID-19). COVID-19 is a disease with highly variable phenotypes, being asymptomatic in most patients. In symptomatic patients, disease manifestation is variable, ranging from mild disease to severe and critical illness requiring treatment in the intensive care unit. The presence of underlying cardiovascular morbidities was identified early in the evolution of the disease to be a critical determinant of the severe disease phenotype. SARS-CoV-2, though a primarily respiratory virus, also causes severe damage to the cardiovascular system, contributing significantly to morbidity and mortality seen in COVID-19. Evidence on the impact of cardiovascular disorders in disease manifestation and outcome of treatment is rapidly emerging. The cardiovascular system expresses the angiotensin-converting enzyme-2, the receptor used by SARS-CoV-2 for binding, making it vulnerable to infection by the virus. Systemic perturbations including the so-called cytokine storm also impact on the normal functioning of the cardiovascular system. Imaging plays a prominent role not only in the detection of cardiovascular damage induced by SARS-CoV-2 infection but in the follow-up of patients' clinical progress while on treatment and in identifying long-term sequelae of the disease.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cardiovascular Diseases / Cardiovascular System / COVID-19 Type of study: Cohort study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: BMC Cardiovasc Disord Journal subject: Vascular Diseases / Cardiology Year: 2022 Document Type: Article Affiliation country: S12872-022-02534-8

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cardiovascular Diseases / Cardiovascular System / COVID-19 Type of study: Cohort study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: BMC Cardiovasc Disord Journal subject: Vascular Diseases / Cardiology Year: 2022 Document Type: Article Affiliation country: S12872-022-02534-8