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Evaluation of menstrual irregularities after COVID-19 vaccination: Results of the MECOVAC survey.
Laganà, Antonio Simone; Veronesi, Giovanni; Ghezzi, Fabio; Ferrario, Marco Mario; Cromi, Antonella; Bizzarri, Mariano; Garzon, Simone; Cosentino, Marco.
  • Laganà AS; Department of Obstetrics and Gynecology, "Filippo Del Ponte" Hospital, University of Insubria, 21100, Varese, Italy.
  • Veronesi G; Department of Medicine and Surgery, School of Medicine, Research Center in Epidemiology and Preventive Medicine, University of Insubria, 21100, Varese, Italy.
  • Ghezzi F; Department of Obstetrics and Gynecology, "Filippo Del Ponte" Hospital, University of Insubria, 21100, Varese, Italy.
  • Ferrario MM; Department of Medicine and Surgery, School of Medicine, Research Center in Epidemiology and Preventive Medicine, University of Insubria, 21100, Varese, Italy.
  • Cromi A; Occupational Medicine Unit, University Hospital of Varese, 21100, Varese, Italy.
  • Bizzarri M; Department of Obstetrics and Gynecology, "Filippo Del Ponte" Hospital, University of Insubria, 21100, Varese, Italy.
  • Garzon S; Department of Experimental Medicine, Systems Biology Group Lab, University La Sapienza, 00161, Rome, Italy.
  • Cosentino M; Department of Obstetrics and Gynaecology, AOUI Verona, University of Verona, 37126, Verona, Italy.
Open Med (Wars) ; 17(1): 475-484, 2022.
Article in English | MEDLINE | ID: covidwho-1736555
ABSTRACT
We investigated menstrual irregularities after the first and second doses of the COVID-19 vaccine. Women answered a customised online questionnaire (ClinicalTrial.gov ID NCT05083065) aimed to assess the vaccine type, the phase of the menstrual cycle during which the vaccine was administered, the occurrence of menstrual irregularities after the first and second doses, and how long this effect lasted. We excluded women with gynaecological and non-gynaecological diseases, undergoing hormonal and non-hormonal treatments, in perimenopause or menopause, as well as those who had irregular menstrual cycles in the last 12 months before vaccine administration. According to our data analysis, approximately 50-60% of reproductive-age women who received the first dose of the COVID-19 vaccine reported menstrual cycle irregularities, regardless of the type of administered vaccine. The occurrence of menstrual irregularities seems to be slightly higher (60-70%) after the second dose. Menstrual irregularities after both the first and second doses of the vaccine were found to self-resolve in approximately half the cases within two months. Based on these results, we suggest to consider these elements during the counselling of women who receive the COVID-19 vaccine, letting them know about the potential occurrence of temporary and self-limiting menstrual cycle irregularities in the subsequent month(s).
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study Topics: Vaccines Language: English Journal: Open Med (Wars) Year: 2022 Document Type: Article Affiliation country: Med-2022-0452

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study Topics: Vaccines Language: English Journal: Open Med (Wars) Year: 2022 Document Type: Article Affiliation country: Med-2022-0452