Association of active immunotherapy with outcomes in cancer patients with COVID-19: a systematic review and meta-analysis.
Aging (Albany NY)
; 14(5): 2062-2080, 2022 03 10.
Article
in English
| MEDLINE | ID: covidwho-1737486
ABSTRACT
BACKGROUND:
During the COVID-19 pandemic, there are growing concerns about the safety of administering immunotherapy in cancer patients with COVID-19. However, current clinical guidelines provided no clear recommendation.METHODS:
Studies were searched and retrieved from electronic databases. The meta-analysis was performed by employing the generic inverse-variance method. A random-effects model was used to calculate the unadjusted odds ratios (ORs) and adjusted ORs with the corresponding 95% CIs.RESULTS:
This meta-analysis included 20 articles with 6,042 cancer patients diagnosed with COVID-19. According to the univariate analysis, the acceptance of immunotherapy within 30 days before COVID-19 diagnosis did not increase the mortality of cancer patients (OR 0.92; 95% CI 0.68-1.25; P=0.61). Moreover, after adjusting for confounders, the adjusted OR for mortality was 0.51, with borderline significance (95% CI 0.25-1.01; P=0.053). Similarly, the univariate analysis showed that the acceptance of immunotherapy within 30 days before COVID-19 diagnosis did not increase the risk of severe/critical disease in cancer patients (OR 1.07; 95% CI 0.78-1.47; P=0.66). No significant between-study heterogeneity was found in these analyses.CONCLUSIONS:
Accepting immunotherapy within 30 days before the diagnosis of COVID-19 was not significantly associated with a higher risk of mortality or severe/critical disease of infected cancer patients. Further prospectively designed studies with large sample sizes are required to evaluate the present results.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Immunotherapy, Active
/
COVID-19
/
Neoplasms
Type of study:
Diagnostic study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
/
Reviews
/
Systematic review/Meta Analysis
Topics:
Long Covid
/
Vaccines
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
/
Young adult
Language:
English
Journal:
Aging (Albany NY)
Journal subject:
Geriatrics
Year:
2022
Document Type:
Article
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