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Outcomes of patients with cancer infected with SARS-CoV-2: results from the Ion Chiricuta Oncology Institute series.
Preda, A; Ciuleanu, T; Kubelac, P; Todor, N; Balacescu, O; Achimas-Cadariu, P; Iancu, D; Mocan, C; Bandi-Vasilica, M; Lupse, M; Briciu, V T; Man, M A; Vlad, C.
  • Preda A; Oncology Institute Prof Dr Ion Chiricuta, Cluj-Napoca, Romania; Iuliu Hatieganu University of Medicine and Pharmacy Oncology, Cluj-Napoca, Romania.
  • Ciuleanu T; Oncology Institute Prof Dr Ion Chiricuta, Cluj-Napoca, Romania; Iuliu Hatieganu University of Medicine and Pharmacy Oncology, Cluj-Napoca, Romania.
  • Kubelac P; Oncology Institute Prof Dr Ion Chiricuta, Cluj-Napoca, Romania. Electronic address: paulkubelac@yahoo.com.
  • Todor N; Oncology Institute Prof Dr Ion Chiricuta, Cluj-Napoca, Romania.
  • Balacescu O; Oncology Institute Prof Dr Ion Chiricuta, Cluj-Napoca, Romania.
  • Achimas-Cadariu P; Oncology Institute Prof Dr Ion Chiricuta, Cluj-Napoca, Romania; Iuliu Hatieganu University of Medicine and Pharmacy Oncology, Cluj-Napoca, Romania.
  • Iancu D; Oncology Institute Prof Dr Ion Chiricuta, Cluj-Napoca, Romania.
  • Mocan C; Oncology Institute Prof Dr Ion Chiricuta, Cluj-Napoca, Romania.
  • Bandi-Vasilica M; Oncology Institute Prof Dr Ion Chiricuta, Cluj-Napoca, Romania.
  • Lupse M; Iuliu Hatieganu University of Medicine and Pharmacy Oncology, Cluj-Napoca, Romania; Infectious Diseases Clinical Hospital, Cluj-Napoca, Romania.
  • Briciu VT; Infectious Diseases Clinical Hospital, Cluj-Napoca, Romania; Pneumology Hospital Leon Daniello Cluj-Napoca, Cluj-Napoca, Romania.
  • Man MA; Iuliu Hatieganu University of Medicine and Pharmacy Oncology, Cluj-Napoca, Romania; Pneumology Hospital Leon Daniello Cluj-Napoca, Cluj-Napoca, Romania.
  • Vlad C; Oncology Institute Prof Dr Ion Chiricuta, Cluj-Napoca, Romania; Iuliu Hatieganu University of Medicine and Pharmacy Oncology, Cluj-Napoca, Romania.
ESMO Open ; 7(2): 100423, 2022 04.
Article in English | MEDLINE | ID: covidwho-1739725
ABSTRACT

BACKGROUND:

The evolution of COVID-19 is a controversial topic in cancer patients. They have been designated by international organizations as a vulnerable population at greater risk for contracting SARS-CoV-2 and having a more severe clinical outcome. PATIENTS AND

METHODS:

Active screening at our institution became routine early in the pandemic. We have examined the clinical data of 341 cancer patients, with a positive RT-PCR SARS-CoV-2 test between April 2020 and February 2021, in the prevaccination era.

RESULTS:

During the infection, 40.5% remained asymptomatic, 27.6% developed a mild form, 20.5% had a moderate form, and 11.4% a severe/critical form of COVID-19 that led to death in 7.6% of cases. Treatment was adapted to disease severity according to national guidelines. In our series, the incidence of COVID-19 infection was lower in cancer patients compared with the general population (P < 0.001), however, the mortality rate was higher in cancer patients in comparison with the general population (7.6% versus 2.9%, P < 0.001). The prognostic factors were assessed by three distinct univariate and multivariate analyses (i) evolution to a moderate or severe/critical clinical manifestation, (ii) clinical worsening (severe/critical form or death), and (iii) overall survival. In the multivariate analysis, the prognostic factors associated with the evolution to a moderate or severe/critical clinical manifestation were performance status (PS) (P < 0.0001) and no active treatment in the previous 3 months (P = 0.031). Factors associated with clinical worsening were PS (P < 0.0001), peripheral arterial disease (P = 0.03), and chronic liver disease (P = 0.04). Factors associated with impaired overall survival were PS (P < 0.0001), ischemic cardiac disease (P = 0.0126), chronic liver disease (P = 0.001), and radiotherapy (P = 0.0027).

CONCLUSION:

Our series confirms a more severe evolution for COVID-19 infection in cancer patients, with PS as the most prominent prognostic factor in all three multivariate analyses. By active screening, efforts should be in place to keep cancer units as coronavirus-free sanctuaries.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Neoplasms Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: ESMO Open Year: 2022 Document Type: Article Affiliation country: J.esmoop.2022.100423

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Neoplasms Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: ESMO Open Year: 2022 Document Type: Article Affiliation country: J.esmoop.2022.100423