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Boosting of SARS-CoV-2 immunity in nonhuman primates using an oral rhabdoviral vaccine.
Peng, Kah-Whye; Carey, Timothy; Lech, Patrycja; Vandergaast, Rianna; Muñoz-Alía, Miguel Á; Packiriswamy, Nandakumar; Gnanadurai, Clement; Krotova, Karina; Tesfay, Mulu; Ziegler, Christopher; Haselton, Michelle; Sevola, Kara; Lathrum, Chase; Reiter, Samantha; Narjari, Riya; Balakrishnan, Baskar; Suksanpaisan, Lukkana; Sakuma, Toshie; Recker, Jordan; Zhang, Lianwen; Waniger, Scott; Russell, Luke; Petro, Christopher D; Kyratsous, Christos A; Baum, Alina; Janecek, Jody L; Lee, Rachael M; Ramachandran, Sabarinathan; Graham, Melanie L; Russell, Stephen J.
  • Peng KW; Vyriad Inc, Rochester MN 55901, USA; Imanis Life Sciences, Rochester MN 55901, USA; Department of Molecular Medicine, Mayo Clinic, MN 55905, USA.
  • Carey T; Imanis Life Sciences, Rochester MN 55901, USA.
  • Lech P; Imanis Life Sciences, Rochester MN 55901, USA.
  • Vandergaast R; Imanis Life Sciences, Rochester MN 55901, USA.
  • Muñoz-Alía MÁ; Department of Molecular Medicine, Mayo Clinic, MN 55905, USA.
  • Packiriswamy N; Department of Molecular Medicine, Mayo Clinic, MN 55905, USA.
  • Gnanadurai C; Imanis Life Sciences, Rochester MN 55901, USA.
  • Krotova K; Imanis Life Sciences, Rochester MN 55901, USA.
  • Tesfay M; Imanis Life Sciences, Rochester MN 55901, USA.
  • Ziegler C; Imanis Life Sciences, Rochester MN 55901, USA.
  • Haselton M; Imanis Life Sciences, Rochester MN 55901, USA.
  • Sevola K; Imanis Life Sciences, Rochester MN 55901, USA.
  • Lathrum C; Imanis Life Sciences, Rochester MN 55901, USA.
  • Reiter S; Imanis Life Sciences, Rochester MN 55901, USA.
  • Narjari R; Imanis Life Sciences, Rochester MN 55901, USA.
  • Balakrishnan B; Department of Molecular Medicine, Mayo Clinic, MN 55905, USA.
  • Suksanpaisan L; Imanis Life Sciences, Rochester MN 55901, USA.
  • Sakuma T; Imanis Life Sciences, Rochester MN 55901, USA.
  • Recker J; Vyriad Inc, Rochester MN 55901, USA.
  • Zhang L; Department of Molecular Medicine, Mayo Clinic, MN 55905, USA.
  • Waniger S; Vyriad Inc, Rochester MN 55901, USA.
  • Russell L; Vyriad Inc, Rochester MN 55901, USA.
  • Petro CD; Regeneron Pharmaceuticals Inc, Tarrytown, NY 10591, USA.
  • Kyratsous CA; Regeneron Pharmaceuticals Inc, Tarrytown, NY 10591, USA.
  • Baum A; Regeneron Pharmaceuticals Inc, Tarrytown, NY 10591, USA.
  • Janecek JL; Department of Surgery, University of Minnesota, USA.
  • Lee RM; Department of Surgery, University of Minnesota, USA.
  • Ramachandran S; Department of Surgery, University of Minnesota, USA.
  • Graham ML; Department of Surgery, University of Minnesota, USA.
  • Russell SJ; Vyriad Inc, Rochester MN 55901, USA; Imanis Life Sciences, Rochester MN 55901, USA; Department of Molecular Medicine, Mayo Clinic, MN 55905, USA. Electronic address: sjrussell@vyriad.com.
Vaccine ; 40(15): 2342-2351, 2022 04 01.
Article in English | MEDLINE | ID: covidwho-1740250
ABSTRACT
An orally active vaccine capable of boosting SARS-CoV-2 immune responses in previously infected or vaccinated individuals would help efforts to achieve and sustain herd immunity. Unlike mRNA-loaded lipid nanoparticles and recombinant replication-defective adenoviruses, replicating vesicular stomatitis viruses with SARS-CoV-2 spike glycoproteins (VSV-SARS2) were poorly immunogenic after intramuscular administration in clinical trials. Here, by G protein trans-complementation, we generated VSV-SARS2(+G) virions with expanded target cell tropism. Compared to parental VSV-SARS2, G-supplemented viruses were orally active in virus-naive and vaccine-primed cynomolgus macaques, powerfully boosting SARS-CoV-2 neutralizing antibody titers. Clinical testing of this oral VSV-SARS2(+G) vaccine is planned.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Rhabdoviridae / Viral Vaccines / COVID-19 Type of study: Prognostic study Topics: Vaccines Limits: Animals Language: English Journal: Vaccine Year: 2022 Document Type: Article Affiliation country: J.vaccine.2021.12.063

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Rhabdoviridae / Viral Vaccines / COVID-19 Type of study: Prognostic study Topics: Vaccines Limits: Animals Language: English Journal: Vaccine Year: 2022 Document Type: Article Affiliation country: J.vaccine.2021.12.063