Marine Natural Products as Leads against SARS-CoV-2 Infection.
J Nat Prod
; 85(3): 657-665, 2022 03 25.
Article
in English
| MEDLINE | ID: covidwho-1740392
ABSTRACT
Since early 2020, disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic, causing millions of infections and deaths worldwide. Despite rapid deployment of effective vaccines, it is apparent that the global community lacks multipronged interventions to combat viral infection and disease. A major limitation is the paucity of antiviral drug options representing diverse molecular scaffolds and mechanisms of action. Here we report the antiviral activities of three distinct marine natural productsâhomofascaplysin A (1), (+)-aureol (2), and bromophycolide A (3)âevidenced by their ability to inhibit SARS-CoV-2 replication at concentrations that are nontoxic toward human airway epithelial cells. These compounds stand as promising candidates for further exploration toward the discovery of novel drug leads against SARS-CoV-2.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Biological Products
/
COVID-19 Drug Treatment
Topics:
Vaccines
Limits:
Humans
Language:
English
Journal:
J Nat Prod
Year:
2022
Document Type:
Article
Affiliation country:
Acs.jnatprod.2c00015
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