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A SARS-CoV-2 Wuhan spike virosome vaccine induces superior neutralization breadth compared to one using the Beta spike.
van der Velden, Yme U; Grobben, Marloes; Caniels, Tom G; Burger, Judith A; Poniman, Meliawati; Oomen, Melissa; Rijnstra, Esther Siteur-van; Tejjani, Khadija; Guerra, Denise; Kempers, Ronald; Stegmann, Toon; van Gils, Marit J; Sanders, Rogier W.
  • van der Velden YU; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, Amsterdam Institute for Infection and Immunity, University of Amsterdam, 1105 AZ, Amsterdam, The Netherlands.
  • Grobben M; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, Amsterdam Institute for Infection and Immunity, University of Amsterdam, 1105 AZ, Amsterdam, The Netherlands.
  • Caniels TG; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, Amsterdam Institute for Infection and Immunity, University of Amsterdam, 1105 AZ, Amsterdam, The Netherlands.
  • Burger JA; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, Amsterdam Institute for Infection and Immunity, University of Amsterdam, 1105 AZ, Amsterdam, The Netherlands.
  • Poniman M; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, Amsterdam Institute for Infection and Immunity, University of Amsterdam, 1105 AZ, Amsterdam, The Netherlands.
  • Oomen M; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, Amsterdam Institute for Infection and Immunity, University of Amsterdam, 1105 AZ, Amsterdam, The Netherlands.
  • Rijnstra ES; Experimental Immunology, Amsterdam UMC, Amsterdam Institute for Infection and Immunity, University of Amsterdam, 1105 AZ, Amsterdam, The Netherlands.
  • Tejjani K; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, Amsterdam Institute for Infection and Immunity, University of Amsterdam, 1105 AZ, Amsterdam, The Netherlands.
  • Guerra D; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, Amsterdam Institute for Infection and Immunity, University of Amsterdam, 1105 AZ, Amsterdam, The Netherlands.
  • Kempers R; Mymetics BV, JH Oortweg 21, 2333 CH, Leiden, The Netherlands.
  • Stegmann T; Mymetics BV, JH Oortweg 21, 2333 CH, Leiden, The Netherlands.
  • van Gils MJ; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, Amsterdam Institute for Infection and Immunity, University of Amsterdam, 1105 AZ, Amsterdam, The Netherlands.
  • Sanders RW; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, Amsterdam Institute for Infection and Immunity, University of Amsterdam, 1105 AZ, Amsterdam, The Netherlands. r.w.sanders@amsterdamumc.nl.
Sci Rep ; 12(1): 3884, 2022 03 10.
Article in English | MEDLINE | ID: covidwho-1740465
ABSTRACT
Current SARS-CoV-2 vaccines are effective, but long-term protection is threatened by the emergence of virus variants. We generated a virosome vaccine containing the Beta spike protein and compared its immunogenicity in mice to a virosome vaccine containing the original Wuhan spike. Two administrations of the virosomes induced potent SARS-CoV-2 neutralizing antibodies in both vaccine groups. The level of autologous neutralization in Beta-vaccinated mice was similar to the level of autologous neutralization in Wuhan-vaccinated mice. However, heterologous neutralization to the Wuhan strain in Beta-vaccinated mice was 4.7-fold lower than autologous neutralization, whereas heterologous neutralization to the Beta strain in Wuhan-vaccinated mice was reduced by only 1.9-fold compared to autologous neutralization levels. In addition, neutralizing activity against the D614G, Alpha and Delta variants was also significantly lower after Beta spike vaccination than after Wuhan spike vaccination. Our results show that Beta spike vaccination induces inferior neutralization breadth. These results are informative for programs aimed to develop broadly active SARS-CoV-2 vaccines.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Spike Glycoprotein, Coronavirus / COVID-19 Vaccines / SARS-CoV-2 Type of study: Experimental Studies / Randomized controlled trials Topics: Vaccines / Variants Limits: Animals Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-022-07590-w

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Spike Glycoprotein, Coronavirus / COVID-19 Vaccines / SARS-CoV-2 Type of study: Experimental Studies / Randomized controlled trials Topics: Vaccines / Variants Limits: Animals Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-022-07590-w