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Anti-SARS-CoV-2 equine F (Ab')2 immunoglobulin as a possible therapy for COVID-19.
Botosso, Viviane Fongaro; Jorge, Soraia Attie Calil; Astray, Renato Mancini; de Sá Guimarães, Ana Marcia; Mathor, Monica Beatriz; de Carneiro, Patrícia Dos Santos; Durigon, Edison Luiz; Covas, Dimas; de Oliveira, Danielle Bruna Leal; das Neves Oliveira, Ricardo; Maria, Durvanei Augusto; Eto, Silas Fernandes; Gallina, Neuza Maria Frazatti; Pidde, Giselle; Squaiella-Baptistão, Carla Cristina; Silva, Dilza Trevisan; Villas-Boas, Isadora Maria; Fernandes, Dayanne Carla; Auada, Aline Vivian Vatti; Banari, Alexandre Campos; de Souza Filho, Antônio Francisco; Bianconi, Camila; de Agostini Utescher, Carla Lilian; Oliveira, Denise Cristina André; Mariano, Douglas Oscar Ceolin; Barbosa, Flávia Ferreira; Rondon, Giuliana; Kapronezai, Josana; da Silva, Juliana Galvão; Goldfeder, Mauricio Barbugiani; Comone, Priscila; Junior, Regis Edgar Castilho; Pereira, Taiana Tainá Silva; Wen, Fan Hui; Tambourgi, Denise V; Chudzinski-Tavassi, Ana Marisa.
  • Botosso VF; Virology Laboratory, Butantan Institute, São Paulo, Brazil.
  • Jorge SAC; Viral Biotechnology Laboratory, Butantan Institute, São Paulo, Brazil.
  • Astray RM; Multipurpose Laboratory, Butantan Institute, São Paulo, Brazil.
  • de Sá Guimarães AM; Microbiology Department, Biomedical Science Institute, University of São Paulo, São Paulo, Brazil.
  • Mathor MB; Institute for Energy and Nuclear Research, São Paulo, Brazil.
  • de Carneiro PDS; Quality Control, Butantan Institute, São Paulo, Brazil.
  • Durigon EL; Microbiology Department, Biomedical Science Institute, University of São Paulo, São Paulo, Brazil.
  • Covas D; Direction, Butantan Institute, São Paulo, Brazil.
  • de Oliveira DBL; Virology Laboratory, Butantan Institute, São Paulo, Brazil.
  • das Neves Oliveira R; Microbiology Department, Biomedical Science Institute, University of São Paulo, São Paulo, Brazil.
  • Maria DA; Bioindustrial Center, Butantan Institute, São Paulo, Brazil.
  • Eto SF; Development and Innovation Laboratory, Butantan Institute, São Paulo, Brazil.
  • Gallina NMF; Development and Innovation Laboratory, Butantan Institute, São Paulo, Brazil.
  • Pidde G; Viral Vaccines Pilot Laboratory, Butantan Institute, São Paulo, Brazil.
  • Squaiella-Baptistão CC; Immunochemistry Laboratory, Butantan Institute, São Paulo, Brazil.
  • Silva DT; Immunochemistry Laboratory, Butantan Institute, São Paulo, Brazil.
  • Villas-Boas IM; Center of Excellence in New Target Discovery (CENTD), Special Laboratory, São Paulo, Brazil.
  • Fernandes DC; Immunochemistry Laboratory, Butantan Institute, São Paulo, Brazil.
  • Auada AVV; Immunochemistry Laboratory, Butantan Institute, São Paulo, Brazil.
  • Banari AC; Bioindustrial Center, Butantan Institute, São Paulo, Brazil.
  • de Souza Filho AF; Microbiology Department, Biomedical Science Institute, University of São Paulo, São Paulo, Brazil.
  • Bianconi C; Microbiology Department, Biomedical Science Institute, University of São Paulo, São Paulo, Brazil.
  • de Agostini Utescher CL; Bioindustrial Center, Butantan Institute, São Paulo, Brazil.
  • Oliveira DCA; Virology Laboratory, Butantan Institute, São Paulo, Brazil.
  • Mariano DOC; Virology Laboratory, Butantan Institute, São Paulo, Brazil.
  • Barbosa FF; Bioindustrial Center, Butantan Institute, São Paulo, Brazil.
  • Rondon G; Multipurpose Laboratory, Butantan Institute, São Paulo, Brazil.
  • Kapronezai J; Development and Innovation Laboratory, Butantan Institute, São Paulo, Brazil.
  • da Silva JG; Virology Laboratory, Butantan Institute, São Paulo, Brazil.
  • Goldfeder MB; Quality Control, Butantan Institute, São Paulo, Brazil.
  • Comone P; Development and Innovation Laboratory, Butantan Institute, São Paulo, Brazil.
  • Junior REC; Bioindustrial Center, Butantan Institute, São Paulo, Brazil.
  • Pereira TTS; Development and Innovation Laboratory, Butantan Institute, São Paulo, Brazil.
  • Wen FH; Microbiology Department, Biomedical Science Institute, University of São Paulo, São Paulo, Brazil.
  • Tambourgi DV; Bioindustrial Center, Butantan Institute, São Paulo, Brazil. fan.hui@butantan.gov.br.
  • Chudzinski-Tavassi AM; Immunochemistry Laboratory, Butantan Institute, São Paulo, Brazil. denise.tambourgi@butantan.gov.br.
Sci Rep ; 12(1): 3890, 2022 03 10.
Article in English | MEDLINE | ID: covidwho-1740469
ABSTRACT
The new outbreak of coronavirus disease 2019 (COVID-19) has infected and caused the death of millions of people worldwide. Intensive efforts are underway around the world to establish effective treatments. Immunoglobulin from immunized animals or plasma from convalescent patients might constitute a specific treatment to guarantee the neutralization of the virus in the early stages of infection, especially in patients with risk factors and a high probability of progressing to severe disease. Worldwide, a few clinical trials using anti-SARS-CoV-2 immunoglobulins from horses immunized with the entire spike protein or fragments of it in the treatment of patients with COVID-19 are underway. Here, we describe the development of an anti-SARS-CoV-2 equine F(ab')2 immunoglobulin using a newly developed SARS-CoV-2 viral antigen that was purified and inactivated by radiation. Cell-based and preclinical assays showed that the F(ab')2 immunoglobulin successfully neutralizes the virus, is safe in animal models, and reduces the severity of the disease in a hamster model of SARS-CoV-2 infection and disease.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulins / Receptors, Immunologic / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Animals / Female / Humans / Male Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-022-07793-1

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulins / Receptors, Immunologic / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Animals / Female / Humans / Male Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-022-07793-1