Synthetic approaches to 1,2,4-triazolo[5,1-c][1,2,4]triazin-7-ones as basic heterocyclic structures of the antiviral drug Riamilovir ("Triazavirin®") active against SARS-CoV-2 (COVID-19).
Org Biomol Chem
; 20(9): 1828-1837, 2022 03 02.
Article
in English
| MEDLINE | ID: covidwho-1740491
ABSTRACT
Fragments of 1,2,4-triazolo[5,1-c][1,2,4]triazin-7-one are found in many compounds with various types of biological activities, including the antiviral drug Riamilovir (Triazavirin®), which shows activity against SARS-CoV-2 (COVID-19). Therefore, the development of convenient methods for the synthesis of new derivatives of 1,2,4-triazolo[5,1-c][1,2,4]triazin-7-one is always in demand. This review systematizes the information on the most common synthetic methods for constructing the 1,2,4-triazolo[5,1-c][1,2,4]triazin-7-one heterocyclic system.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Triazines
Language:
English
Journal:
Org Biomol Chem
Journal subject:
Biochemistry
/
Chemistry
Year:
2022
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS