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Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 in the Serum and Cerebrospinal Fluid of Patients With Coronavirus Disease 2019 and Neurological Symptoms.
Cunningham, Janet L; Virhammar, Johan; Rönnberg, Bengt; Dopico, Xaquin Castro; Kolstad, Linda; Albinsson, Bo; Kumlien, Eva; Nääs, Anja; Klang, Andrea; Westman, Gabriel; Zetterberg, Henrik; Frithiof, Robert; Lundkvist, Åke; Karlsson Hedestam, Gunilla B; Rostami, Elham.
  • Cunningham JL; Department of Neuroscience, Psychiatry, Uppsala University, Uppsala, Sweden.
  • Virhammar J; Department of Neuroscience, Neurology, Uppsala University, Uppsala, Sweden.
  • Rönnberg B; Laboratory of Clinical Microbiology at Uppsala University Hospital, Uppsala, Sweden.
  • Dopico XC; Department of Medical Biochemistry and Microbiology, Zoonosis Science Center, Uppsala University, Uppsala, Sweden.
  • Kolstad L; Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
  • Albinsson B; Department of Medical Biochemistry and Microbiology, Zoonosis Science Center, Uppsala University, Uppsala, Sweden.
  • Kumlien E; Laboratory of Clinical Microbiology at Uppsala University Hospital, Uppsala, Sweden.
  • Nääs A; Department of Medical Biochemistry and Microbiology, Zoonosis Science Center, Uppsala University, Uppsala, Sweden.
  • Klang A; Department of Neuroscience, Neurology, Uppsala University, Uppsala, Sweden.
  • Westman G; Department of Medical Sciences, Section of Infectious Diseases, Uppsala University, Uppsala, Sweden.
  • Zetterberg H; Department of Neuroscience, Rehabilitation Medicine, Uppsala University, Uppsala, Sweden.
  • Frithiof R; Department of Medical Sciences, Section of Infectious Diseases, Uppsala University, Uppsala, Sweden.
  • Lundkvist Å; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
  • Karlsson Hedestam GB; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
  • Rostami E; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, United Kingdom.
J Infect Dis ; 225(6): 965-970, 2022 03 15.
Article in English | MEDLINE | ID: covidwho-1740882
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. Neurologic Symptoms PROCESS_OF Patients
Subject
Neurologic Symptoms
Predicate
PROCESS_OF
Object
Patients
3. Cerebrospinal Fluid PART_OF Patients
Subject
Cerebrospinal Fluid
Predicate
PART_OF
Object
Patients
4. Serum PART_OF Patients
Subject
Serum
Predicate
PART_OF
Object
Patients
5. Serum LOCATION_OF Viral Proteins
Subject
Serum
Predicate
LOCATION_OF
Object
Viral Proteins
6. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
7. Neurologic Symptoms PROCESS_OF Patients
Subject
Neurologic Symptoms
Predicate
PROCESS_OF
Object
Patients
8. Cerebrospinal Fluid PART_OF Patients
Subject
Cerebrospinal Fluid
Predicate
PART_OF
Object
Patients
9. Serum PART_OF Patients
Subject
Serum
Predicate
PART_OF
Object
Patients
10. Serum LOCATION_OF Viral Proteins
Subject
Serum
Predicate
LOCATION_OF
Object
Viral Proteins
ABSTRACT
Antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in serum and cerebrospinal fluid (CSF) samples from 16 patients with coronavirus disease 2019 and neurological symptoms were assessed using 2 independent methods. Immunoglobulin G (IgG) specific for the virus spike protein was found in 81% of patients in serum and in 56% in CSF. SARS-CoV-2 IgG in CSF was observed in 2 patients with negative serological findings. Levels of IgG in both serum and CSF were associated with disease severity (P < .05). All patients with elevated markers of central nervous system damage in CSF also had CSF antibodies (P = .002), and CSF antibodies had the highest predictive value for neuronal damage markers of all tested clinical variables.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin G / SARS-CoV-2 / COVID-19 / Antibodies, Viral / Nervous System Diseases Type of study: Diagnostic study / Etiology study / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin G / SARS-CoV-2 / COVID-19 / Antibodies, Viral / Nervous System Diseases Type of study: Diagnostic study / Etiology study / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis