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The Anti-COVID-19 Drug Remdesivir Promotes Oncogenic Herpesvirus Reactivation through Regulation of Intracellular Signaling Pathways.
Chen, Jungang; Dai, Lu; Kendrick, Samantha; Post, Steven R; Qin, Zhiqiang.
  • Chen J; Departments of Pathology, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
  • Dai L; Departments of Pathology, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
  • Kendrick S; Biochemistry and Molecular Biology, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
  • Post SR; Departments of Pathology, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
  • Qin Z; Departments of Pathology, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Antimicrob Agents Chemother ; 66(3): e0239521, 2022 03 15.
Article in English | MEDLINE | ID: covidwho-1741569
ABSTRACT
Recently, remdesivir and molnupiravir were approved for treating COVID-19 caused by SARS-CoV-2 infection. However, little is known about the impact of these drugs on other viruses preexisted in COVID-19 patients. Here we report that remdesivir but not molnupiravir induced lytic reactivation of Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV), two major oncogenic herpesviruses. Remdesivir induced mature virion production from latently infected cells. Mechanistic studies showed that remdesivir induced KSHV and EBV reactivation by regulating several intracellular signaling pathways.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Herpesvirus 8, Human / Epstein-Barr Virus Infections / COVID-19 Drug Treatment Limits: Humans Language: English Journal: Antimicrob Agents Chemother Year: 2022 Document Type: Article Affiliation country: Aac.02395-21

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Herpesvirus 8, Human / Epstein-Barr Virus Infections / COVID-19 Drug Treatment Limits: Humans Language: English Journal: Antimicrob Agents Chemother Year: 2022 Document Type: Article Affiliation country: Aac.02395-21