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Quantitative Chest CT Assessment of Small Airways Disease in Post-Acute SARS-CoV-2 Infection.
Cho, Josalyn L; Villacreses, Raul; Nagpal, Prashant; Guo, Junfeng; Pezzulo, Alejandro A; Thurman, Andrew L; Hamzeh, Nabeel Y; Blount, Robert J; Fortis, Spyridon; Hoffman, Eric A; Zabner, Joseph; Comellas, Alejandro P.
  • Cho JL; From the Division of Pulmonary, Critical Care and Occupational Medicine, Department of Internal Medicine (J.L.C., R.V., A.A.P., A.L.T., N.Y.H., R.J.B., S.F., E.A.H., J.Z., A.P.C.), Department of Radiology (P.N., J.G., E.A.H.), and Roy J. Carver Department of Biomedical Engineering (J.G., E.A.H.), Ca
  • Villacreses R; From the Division of Pulmonary, Critical Care and Occupational Medicine, Department of Internal Medicine (J.L.C., R.V., A.A.P., A.L.T., N.Y.H., R.J.B., S.F., E.A.H., J.Z., A.P.C.), Department of Radiology (P.N., J.G., E.A.H.), and Roy J. Carver Department of Biomedical Engineering (J.G., E.A.H.), Ca
  • Nagpal P; From the Division of Pulmonary, Critical Care and Occupational Medicine, Department of Internal Medicine (J.L.C., R.V., A.A.P., A.L.T., N.Y.H., R.J.B., S.F., E.A.H., J.Z., A.P.C.), Department of Radiology (P.N., J.G., E.A.H.), and Roy J. Carver Department of Biomedical Engineering (J.G., E.A.H.), Ca
  • Guo J; From the Division of Pulmonary, Critical Care and Occupational Medicine, Department of Internal Medicine (J.L.C., R.V., A.A.P., A.L.T., N.Y.H., R.J.B., S.F., E.A.H., J.Z., A.P.C.), Department of Radiology (P.N., J.G., E.A.H.), and Roy J. Carver Department of Biomedical Engineering (J.G., E.A.H.), Ca
  • Pezzulo AA; From the Division of Pulmonary, Critical Care and Occupational Medicine, Department of Internal Medicine (J.L.C., R.V., A.A.P., A.L.T., N.Y.H., R.J.B., S.F., E.A.H., J.Z., A.P.C.), Department of Radiology (P.N., J.G., E.A.H.), and Roy J. Carver Department of Biomedical Engineering (J.G., E.A.H.), Ca
  • Thurman AL; From the Division of Pulmonary, Critical Care and Occupational Medicine, Department of Internal Medicine (J.L.C., R.V., A.A.P., A.L.T., N.Y.H., R.J.B., S.F., E.A.H., J.Z., A.P.C.), Department of Radiology (P.N., J.G., E.A.H.), and Roy J. Carver Department of Biomedical Engineering (J.G., E.A.H.), Ca
  • Hamzeh NY; From the Division of Pulmonary, Critical Care and Occupational Medicine, Department of Internal Medicine (J.L.C., R.V., A.A.P., A.L.T., N.Y.H., R.J.B., S.F., E.A.H., J.Z., A.P.C.), Department of Radiology (P.N., J.G., E.A.H.), and Roy J. Carver Department of Biomedical Engineering (J.G., E.A.H.), Ca
  • Blount RJ; From the Division of Pulmonary, Critical Care and Occupational Medicine, Department of Internal Medicine (J.L.C., R.V., A.A.P., A.L.T., N.Y.H., R.J.B., S.F., E.A.H., J.Z., A.P.C.), Department of Radiology (P.N., J.G., E.A.H.), and Roy J. Carver Department of Biomedical Engineering (J.G., E.A.H.), Ca
  • Fortis S; From the Division of Pulmonary, Critical Care and Occupational Medicine, Department of Internal Medicine (J.L.C., R.V., A.A.P., A.L.T., N.Y.H., R.J.B., S.F., E.A.H., J.Z., A.P.C.), Department of Radiology (P.N., J.G., E.A.H.), and Roy J. Carver Department of Biomedical Engineering (J.G., E.A.H.), Ca
  • Hoffman EA; From the Division of Pulmonary, Critical Care and Occupational Medicine, Department of Internal Medicine (J.L.C., R.V., A.A.P., A.L.T., N.Y.H., R.J.B., S.F., E.A.H., J.Z., A.P.C.), Department of Radiology (P.N., J.G., E.A.H.), and Roy J. Carver Department of Biomedical Engineering (J.G., E.A.H.), Ca
  • Zabner J; From the Division of Pulmonary, Critical Care and Occupational Medicine, Department of Internal Medicine (J.L.C., R.V., A.A.P., A.L.T., N.Y.H., R.J.B., S.F., E.A.H., J.Z., A.P.C.), Department of Radiology (P.N., J.G., E.A.H.), and Roy J. Carver Department of Biomedical Engineering (J.G., E.A.H.), Ca
  • Comellas AP; From the Division of Pulmonary, Critical Care and Occupational Medicine, Department of Internal Medicine (J.L.C., R.V., A.A.P., A.L.T., N.Y.H., R.J.B., S.F., E.A.H., J.Z., A.P.C.), Department of Radiology (P.N., J.G., E.A.H.), and Roy J. Carver Department of Biomedical Engineering (J.G., E.A.H.), Ca
Radiology ; 304(1): 185-192, 2022 07.
Article in English | MEDLINE | ID: covidwho-1741709
ABSTRACT
Background The long-term effects of SARS-CoV-2 infection on pulmonary structure and function remain incompletely characterized. Purpose To test whether SARS-CoV-2 infection leads to small airways disease in patients with persistent symptoms. Materials and Methods In this single-center study at a university teaching hospital, adults with confirmed COVID-19 who remained symptomatic more than 30 days following diagnosis were prospectively enrolled from June to December 2020 and compared with healthy participants (controls) prospectively enrolled from March to August 2018. Participants with post-acute sequelae of COVID-19 (PASC) were classified as ambulatory, hospitalized, or having required the intensive care unit (ICU) based on the highest level of care received during acute infection. Symptoms, pulmonary function tests, and chest CT images were collected. Quantitative CT analysis was performed using supervised machine learning to measure regional ground-glass opacity (GGO) and using inspiratory and expiratory image-matching to measure regional air trapping. Univariable analyses and multivariable linear regression were used to compare groups. Results Overall, 100 participants with PASC (median age, 48 years; 66 women) were evaluated and compared with 106 matched healthy controls; 67% (67 of 100) of the participants with PASC were classified as ambulatory, 17% (17 of 100) were hospitalized, and 16% (16 of 100) required the ICU. In the hospitalized and ICU groups, the mean percentage of total lung classified as GGO was 13.2% and 28.7%, respectively, and was higher than that in the ambulatory group (3.7%, P < .001 for both comparisons). The mean percentage of total lung affected by air trapping was 25.4%, 34.6%, and 27.3% in the ambulatory, hospitalized, and ICU groups, respectively, and 7.2% in healthy controls (P < .001). Air trapping correlated with the residual volume-to-total lung capacity ratio (ρ = 0.6, P < .001). Conclusion In survivors of COVID-19, small airways disease occurred independently of initial infection severity. The long-term consequences are unknown. © RSNA, 2022 Online supplemental material is available for this article. See also the editorial by Elicker in this issue.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Lung Diseases Type of study: Diagnostic study / Experimental Studies / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Female / Humans / Male / Middle aged Language: English Journal: Radiology Year: 2022 Document Type: Article Affiliation country: Radiol.212170

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Lung Diseases Type of study: Diagnostic study / Experimental Studies / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Female / Humans / Male / Middle aged Language: English Journal: Radiology Year: 2022 Document Type: Article Affiliation country: Radiol.212170