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Interfering with Host Proteases in SARS-CoV-2 Entry as a Promising Therapeutic Strategy.
Müller, Patrick; Maus, Hannah; Hammerschmidt, Stefan Josef; Knaff, Philip Maximilian; Mailänder, Volker; Schirmeister, Tanja; Kersten, Christian.
  • Müller P; Institute for Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Staudingerweg 5, 55128 Mainz, Germany.
  • Maus H; Institute for Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Staudingerweg 5, 55128 Mainz, Germany.
  • Hammerschmidt SJ; Institute for Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Staudingerweg 5, 55128 Mainz, Germany.
  • Knaff PM; Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.
  • Mailänder V; Dermatology Clinic of the University Medicine, Johannes Gutenberg-University Mainz, Langenbeckstr. 1, 55131 Mainz, Germany.
  • Schirmeister T; Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.
  • Kersten C; Dermatology Clinic of the University Medicine, Johannes Gutenberg-University Mainz, Langenbeckstr. 1, 55131 Mainz, Germany.
Curr Med Chem ; 29(4): 635-665, 2022.
Article in English | MEDLINE | ID: covidwho-1742086
Semantic information from SemMedBD (by NLM)
1. New medications TREATS Disease
Subject
New medications
Predicate
TREATS
Object
Disease
2. New medications TREATS Disease
Subject
New medications
Predicate
TREATS
Object
Disease
ABSTRACT
Due to its fast international spread and substantial mortality, the coronavirus disease COVID-19 evolved to a global threat. Since there is currently no causative drug against this viral infection available, science is striving for new drugs and other approaches to treat the new disease. Studies have shown that the cell entry of coronaviruses into host cells takes place through the binding of the viral spike (S) protein to cell receptors. Priming of the S protein occurs via hydrolysis by different host proteases. The inhibition of these proteases could impair the processing of the S protein, thereby affecting the interaction with the host-cell receptors and preventing virus cell entry. Hence, inhibition of these proteases could be a promising strategy for treatment against SARSCoV- 2. In this review, we discuss the current state of the art of developing inhibitors against the entry proteases furin, the transmembrane serine protease type-II (TMPRSS2), trypsin, and cathepsin L.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Limits: Humans Language: English Journal: Curr Med Chem Journal subject: Chemistry Year: 2022 Document Type: Article Affiliation country: 0929867328666210526111318

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Limits: Humans Language: English Journal: Curr Med Chem Journal subject: Chemistry Year: 2022 Document Type: Article Affiliation country: 0929867328666210526111318