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Statin Use in COVID-19 Hospitalized Patients and Outcomes: A Retrospective Study.
Kouhpeikar, Hamideh; Khosaravizade Tabasi, Hamidreza; Khazir, Zahra; Naghipour, Armin; Mohammadi Moghadam, Hussein; Forouzanfar, Hasan; Abbasifard, Mitra; Kirichenko, Tatiana V; Reiner, Zeljko; Banach, Maciej; Sahebkar, Amirhossein.
  • Kouhpeikar H; Department of Hematology and Blood Bank, Tabas School of Nursing, Birjand University of Medical Science, Birjand, Iran.
  • Khosaravizade Tabasi H; Department of Nursing, Tabas School of Nursing, Birjand University of Medical Science, Birjand, Iran.
  • Khazir Z; Department of Nursing, Tabas School of Nursing, Birjand University of Medical Science, Birjand, Iran.
  • Naghipour A; Department of Biostatistics and Epidemiology, Hamadan-Iran Clinical Research Development Center, Imam Reza Hospital, Hamadan University of Medical Sciences, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Mohammadi Moghadam H; Department of Nursing, Tabas School of Nursing, Birjand University of Medical Science, Birjand, Iran.
  • Forouzanfar H; Department of Nursing, Tabas School of Nursing, Birjand University of Medical Science, Birjand, Iran.
  • Abbasifard M; Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
  • Kirichenko TV; Department of Internal Medicine, Ali-Ibn Abi-Talib Hospital, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
  • Reiner Z; Laboratory of Cellular and Molecular Pathology of Cardiovascular System, AP Avtsyn Research Institute of Human Morphology, Moscow, Russia.
  • Banach M; Department of Internal Medicine, School of Medicine, University Hospital Centre Zagreb, University of Zagreb, Zagreb, Croatia.
  • Sahebkar A; Department of Preventive Cardiology and Lipidology, Chair of Nephrology and Hypertension, Medical University of Lodz, Lódz, Poland.
Front Cardiovasc Med ; 9: 820260, 2022.
Article in English | MEDLINE | ID: covidwho-1742209
ABSTRACT

Background:

Coronavirus disease 2019 (COVID-19) might affect everyone, but people with comorbidities such as hypertension and cardiovascular disease (CVD) may often have more severe complications and worse outcomes. Although vaccinations are being performed worldwide, it will take a long time until the entire population of the world is vaccinated. On the other hand, we are witnessing the emergence of new variants of this virus. Therefore, effective therapeutic approaches still need to be considered. Statins are well-known lipid-lowering drugs, but they have also anti-inflammatory and immunomodulatory effects. This study aimed to investigate the effects of statins on the survival of COVID-19 hospitalized patients.

Methods:

This retrospective study was performed on 583 patients admitted to a highly referenced hospital in Tabas, Iran, between February 2020 and December 2020. One hundred sixty-two patients were treated with statins and 421 patients were not. Demographic information, clinical signs, and the results of laboratory, and comorbidities were extracted from patients' medical records and mortality and survival rates were assessed in these two groups.

Results:

The results of the Cox crude regression model showed that statins reduced mortality in COVID-19 patients (HR = 0.56, 95% CI 0.32, 0.97; p = 0.040), although this reduction was not significant in the adjusted model (HRs=0.51, 95%CI 0.22, 1.17; p = 0.114). Using a composite outcome comprising intubation, ICU admission, and mortality, both crude (HR = 0.43; 95% CI 0.26, 0.73; p = 0.002) and adjusted (HR = 0.57; 95% CI 0.33, 0.99; p = 0.048) models suggested a significant protective effect of statin therapy.

Conclusion:

Due to anti-inflammatory properties of statins, these drugs can be effective as an adjunct therapy in the treatment of COVID-19 patients.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines / Variants Language: English Journal: Front Cardiovasc Med Year: 2022 Document Type: Article Affiliation country: Fcvm.2022.820260

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines / Variants Language: English Journal: Front Cardiovasc Med Year: 2022 Document Type: Article Affiliation country: Fcvm.2022.820260