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SARS-CoV-2 Induces Cytokine Responses in Human Basophils.
Bonam, Srinivasa Reddy; Chauvin, Camille; Levillayer, Laurine; Mathew, Mano Joseph; Sakuntabhai, Anavaj; Bayry, Jagadeesh.
  • Bonam SR; Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, Sorbonne Université, Université de Paris, Paris, France.
  • Chauvin C; Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, Sorbonne Université, Université de Paris, Paris, France.
  • Levillayer L; Functional Genetics of Infectious Diseases Unit, Department of Global Health, Institut Pasteur, Paris, France.
  • Mathew MJ; Functional Genetics of Infectious Diseases Unit, Department of Global Health, Institut Pasteur, Paris, France.
  • Sakuntabhai A; EFREI, Villejuif, France.
  • Bayry J; Functional Genetics of Infectious Diseases Unit, Department of Global Health, Institut Pasteur, Paris, France.
Front Immunol ; 13: 838448, 2022.
Article in English | MEDLINE | ID: covidwho-1742220
ABSTRACT
Basophils play a key role in the orientation of immune responses. Though the interaction of SARS-CoV-2 with various immune cells has been relatively well studied, the response of basophils to this pandemic virus is not characterized yet. In this study, we report that SARS-CoV-2 induces cytokine responses and in particular IL-13, in both resting and IL-3 primed basophils. The response was prominent under IL-3 primed condition. However, either SARS-CoV-2 or SARS-CoV-2-infected epithelial cells did not alter the expression of surface markers associated with the activation of basophils, such as CD69, CD13 and/or degranulation marker CD107a. We also validate that human basophils are not permissive to SARS-CoV-2 replication. Though increased expression of immune checkpoint molecule PD-L1 has been reported on the basophils from COVID-19 patients, we observed that SARS-CoV-2 does not induce PD-L1 on the basophils. Our data suggest that basophil cytokine responses to SARS-CoV-2 might help in reducing the inflammation and also to promote antibody responses to the virus.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Basophils / Interleukin-13 / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Front Immunol Year: 2022 Document Type: Article Affiliation country: Fimmu.2022.838448

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Basophils / Interleukin-13 / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Front Immunol Year: 2022 Document Type: Article Affiliation country: Fimmu.2022.838448