IFN-γ Induces PD-L1 Expression in Primed Human Basophils.
Cells
; 11(5)2022 02 25.
Article
in English
| MEDLINE | ID: covidwho-1742338
ABSTRACT
Programmed death-ligand 1 (PD-L1) plays a key role in maintaining immune tolerance and also in immune evasion of cancers and pathogens. Though the identity of stimuli that induce PD-L1 in various human innate cells and their function are relatively well studied, data on the basophils remain scarce. In this study, we have identified one of the factors, such as IFN-γ, that induces PD-L1 expression in human basophils. Interestingly, we found that basophil priming by IL-3 is indispensable for IFN-γ-induced PD-L1 expression in human basophils. However, priming by other cytokines including granulocyte-macrophage colony-stimulating factor (GM-CSF) and thymic stromal lymphopoietin (TSLP) was dispensable. Analyses of a published microarray data set on IL-3-treated basophils indicated that IL-3 enhances IFNGR2, one of the chains of the IFNGR heterodimer complex, and CD274, thus providing a mechanistic insight into the role of IL-3 priming in IFN-γ-induced PD-L1 expression in human basophils.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Basophils
/
B7-H1 Antigen
Limits:
Humans
Language:
English
Year:
2022
Document Type:
Article
Affiliation country:
Cells11050801
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