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Characteristics and Outcomes of COVID-19-Related Hospitalization among PLWH.
Gagliardini, Roberta; Vergori, Alessandra; Lorenzini, Patrizia; Cicalini, Stefania; Pinnetti, Carmela; Mazzotta, Valentina; Mondi, Annalisa; Mastrorosa, Ilaria; Camici, Marta; Lanini, Simone; Fusto, Marisa; Paulicelli, Jessica; Plazzi, Maria Maddalena; Marchioni, Luisa; Agrati, Chiara; Garbuglia, Anna Rosa; Piselli, Pierluca; Nicastri, Emanuele; Taglietti, Fabrizio; Palmieri, Fabrizio; D'Offizi, Gianpiero; Girardi, Enrico; Vaia, Francesco; Antinori, Andrea.
  • Gagliardini R; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Via Portuense, 292, 00149 Roma, Italy.
  • Vergori A; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Via Portuense, 292, 00149 Roma, Italy.
  • Lorenzini P; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Via Portuense, 292, 00149 Roma, Italy.
  • Cicalini S; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Via Portuense, 292, 00149 Roma, Italy.
  • Pinnetti C; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Via Portuense, 292, 00149 Roma, Italy.
  • Mazzotta V; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Via Portuense, 292, 00149 Roma, Italy.
  • Mondi A; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Via Portuense, 292, 00149 Roma, Italy.
  • Mastrorosa I; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Via Portuense, 292, 00149 Roma, Italy.
  • Camici M; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Via Portuense, 292, 00149 Roma, Italy.
  • Lanini S; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Via Portuense, 292, 00149 Roma, Italy.
  • Fusto M; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Via Portuense, 292, 00149 Roma, Italy.
  • Paulicelli J; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Via Portuense, 292, 00149 Roma, Italy.
  • Plazzi MM; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Via Portuense, 292, 00149 Roma, Italy.
  • Marchioni L; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Via Portuense, 292, 00149 Roma, Italy.
  • Agrati C; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Via Portuense, 292, 00149 Roma, Italy.
  • Garbuglia AR; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Via Portuense, 292, 00149 Roma, Italy.
  • Piselli P; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Via Portuense, 292, 00149 Roma, Italy.
  • Nicastri E; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Via Portuense, 292, 00149 Roma, Italy.
  • Taglietti F; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Via Portuense, 292, 00149 Roma, Italy.
  • Palmieri F; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Via Portuense, 292, 00149 Roma, Italy.
  • D'Offizi G; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Via Portuense, 292, 00149 Roma, Italy.
  • Girardi E; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Via Portuense, 292, 00149 Roma, Italy.
  • Vaia F; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Via Portuense, 292, 00149 Roma, Italy.
  • Antinori A; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Via Portuense, 292, 00149 Roma, Italy.
J Clin Med ; 11(6)2022 Mar 11.
Article in English | MEDLINE | ID: covidwho-1742502
ABSTRACT

BACKGROUND:

There is conflicting evidence for how HIV influences COVID-19 infection. The aim of this study was to compare characteristics at presentation and the clinical outcomes of people living with HIV (PLWH) versus HIV-negative patients (non-PLWH) hospitalized with COVID-19.

METHODS:

Primary endpoint time until invasive ventilation/death. Secondary endpoints time until ventilation/death, time until symptoms resolution.

RESULTS:

A total of 1647 hospitalized patients were included (43 (2.6%) PLWH, 1604 non-PLWH). PLWH were younger (55 vs. 61 years) and less likely to be with PaO2/FiO2 < 300 mmHg compared with non-PLWH. Among PLWH, nadir of CD4 was 185 (75-322) cells/µL; CD4 at COVID-19 diagnosis was 272 cells/µL (127-468) and 77% of these were virologically suppressed. The cumulative probability of invasive mechanical ventilation/death at day 15 was 4.7% (95%CI 1.2-17.3) in PLWH versus 18.9% (16.9-21.1) in non-PLWH (p = 0.023). The cumulative probability of non-invasive/invasive ventilation/death at day 15 was 20.9% (11.5-36.4) in PLWH versus 37.6% (35.1-40.2) in non-PLWH (p = 0.044). The adjusted hazard ratio (aHR) of invasive mechanical ventilation/death of PLWH was 0.49 (95% CI 0.12-1.96, p = 0.310) versus non-PLWH; similarly, aHR of non-invasive/invasive ventilation/death of PLWH was 1.03 (95% CI 0.53-2.00, p = 0.926).

CONCLUSION:

A less-severe presentation of COVID-19 at hospitalization was observed in PLWH compared to non-PLWH; no difference in clinical outcomes could be detected.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Year: 2022 Document Type: Article Affiliation country: Jcm11061546

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Year: 2022 Document Type: Article Affiliation country: Jcm11061546