A Helquat-like Compound as a Potent Inhibitor of Flaviviral and Coronaviral Polymerases.
Molecules
; 27(6)2022 Mar 15.
Article
in English
| MEDLINE | ID: covidwho-1742558
ABSTRACT
Positive-sense single-stranded RNA (+RNA) viruses have proven to be important pathogens that are able to threaten and deeply damage modern societies, as illustrated by the ongoing COVID-19 pandemic. Therefore, compounds active against most or many +RNA viruses are urgently needed. Here, we present PR673, a helquat-like compound that is able to inhibit the replication of SARS-CoV-2 and tick-borne encephalitis virus in cell culture. Using in vitro polymerase assays, we demonstrate that PR673 inhibits RNA synthesis by viral RNA-dependent RNA polymerases (RdRps). Our results illustrate that the development of broad-spectrum non-nucleoside inhibitors of RdRps is feasible.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Encephalitis Viruses, Tick-Borne
/
COVID-19
Limits:
Humans
Language:
English
Journal subject:
Biology
Year:
2022
Document Type:
Article
Affiliation country:
Molecules27061894
Similar
MEDLINE
...
LILACS
LIS