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A Review on Xerostomia and Its Various Management Strategies: The Role of Advanced Polymeric Materials in the Treatment Approaches.
Kapourani, Afroditi; Kontogiannopoulos, Konstantinos N; Manioudaki, Alexandra-Eleftheria; Poulopoulos, Athanasios K; Tsalikis, Lazaros; Assimopoulou, Andreana N; Barmpalexis, Panagiotis.
  • Kapourani A; Department of Pharmaceutical Technology, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
  • Kontogiannopoulos KN; Department of Pharmaceutical Technology, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
  • Manioudaki AE; Department of Pharmaceutical Technology, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
  • Poulopoulos AK; Department of Oral Medicine and Maxillofacial Pathology, School of Dentistry, Aristotle University, 54124 Thessaloniki, Greece.
  • Tsalikis L; Department of Preventive Dentistry, Periodontology and Implant Biology, School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
  • Assimopoulou AN; Laboratory of Organic Chemistry, School of Chemical Engineering, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
  • Barmpalexis P; Natural Products Research Centre of Excellence-AUTH (NatPro-AUTH), Center for Interdisciplinary Research and Innovation (CIRI-AUTH), 57001 Thessaloniki, Greece.
Polymers (Basel) ; 14(5)2022 Feb 22.
Article in English | MEDLINE | ID: covidwho-1742589
ABSTRACT
The medical term xerostomia refers to the subjective sensation of oral dryness. The etiology seems to be multifactorial with the most frequently reported causes being the use of xerostomic medications, neck and head radiation, and systematic diseases (such as Sjögren's syndrome). Xerostomia is associated with an increased incidence of dental caries, oral fungal infections, and difficulties in speaking and chewing/swallowing, which ultimately affect the oral health-related quality of life. The development of successful management schemes is regarded as a highly challenging project due to the complexity of saliva. This is why, in spite of the fact that there are therapeutic options aiming to improve salivary function, most management approaches are alleviation-oriented. In any case, polymers are an integral part of the various formulations used in every current treatment approach, especially in the saliva substitutes, due to their function as thickening and lubricating agents or, in the case of mucoadhesive polymers, their ability to prolong the treatment effect. In this context, the present review aims to scrutinize the literature and presents an overview of the role of various polymers (or copolymers) on either already commercially available formulations or novel drug delivery systems currently under research and development.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Etiology study / Observational study / Systematic review/Meta Analysis Language: English Year: 2022 Document Type: Article Affiliation country: Polym14050850

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Etiology study / Observational study / Systematic review/Meta Analysis Language: English Year: 2022 Document Type: Article Affiliation country: Polym14050850