Your browser doesn't support javascript.
Clinical, Laboratory and Imaging Characteristics of Hospitalized COVID-19 Patients with Neurologic Involvement; a Cross-Sectional Study.
Zare Dehnavi, Ali; Salehi, Mohammadreza; Arab Ahmadi, Mehran; Asgardoon, Mohammad Hossein; Ashrafi, Farzad; Ahmadinejad, Nasrin; Behkar, Atefeh; Hamidi Farahani, Ramin; Hashemi, Hassan; Tafakhori, Abbas; Shahali, Hamze; Rahmani, Mohammad; Ranjbar Naeini, Alireza.
  • Zare Dehnavi A; Department of Neurology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran.
  • Salehi M; Infectious Diseases and Tropical Medicines Department, Tehran University of Medical Sciences, Tehran, Iran.
  • Arab Ahmadi M; Advanced Diagnostic and Interventional Radiology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Asgardoon MH; School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Ashrafi F; Functional Neurosurgery Research Center, Shohadaye Tajrish Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Ahmadinejad N; Advanced Diagnostic and Interventional Radiology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Behkar A; School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Hamidi Farahani R; Department of Infectious Disease, AJA University of Medical Sciences, Tehran, Iran.
  • Hashemi H; Advanced Diagnostic and Interventional Radiology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Tafakhori A; Department of Neurology, School of Medicine, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Shahali H; Department of Aerospace and Sub Aquatic Medicine, AJA University of Medical Sciences, Tehran, Iran.
  • Rahmani M; Department of Neurology, School of Medicine, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Ranjbar Naeini A; Department of Neurology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran.
Arch Acad Emerg Med ; 10(1): e10, 2022.
Article in English | MEDLINE | ID: covidwho-1743129
ABSTRACT

Introduction:

Although neurologic involvement and neuroimaging abnormalities have been frequently identified in COVID-19 patients, the underlying factors remain unclear. In this study, we assessed the association of the neurological manifestations and neuroimaging features of hospitalized COVID-19 patients with their clinical, laboratory, and imaging characteristics.

Methods:

This multicenter cross-sectional study was conducted between September 2020 and March 2021 at two large academic hospitals in Tehran, Iran. We used census sampling from medical records to enroll hospitalized patients with a positive COVID-19 Polymerase chain reaction (PCR) test who underwent brain imaging due to presenting any acute neurologic symptom during hospital stay.

Results:

Of the 4372 hospitalized patients with COVID-19, only 211 met the inclusion criteria (35.5% with severe infection). Central nervous system and psychiatric manifestations were significantly more common in severe cases (p ≤ 0.044). Approximately, 30% had a new abnormality on their neuroimaging, with ischemic (38/63) and hemorrhagic (16/63) insults being the most common. The most frequent reasons that provoked cranial imaging were headache (27%), altered consciousness (25.6%), focal neurologic signs (19.9%), and delirium (18%). Analysis revealed a positive correlation for age, neutrophilia, lymphopenia, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) with the emergence of neuroimaging abnormalities (p ≤ 0.018). In addition, patients with new neuroimaging abnormalities had a significantly higher lung CT score than those without any pathologic findings (11.1 ± 4.8 vs. 5.9 ± 4.8, p < 0.001).

Conclusion:

Approximately 30% of the study population had various acute neuroimaging findings. The lung CT score, neutrophil count, and age were strong predictors of acute neuroimaging abnormalities in hospitalized COVID-19 patients.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study / Randomized controlled trials Language: English Journal: Arch Acad Emerg Med Year: 2022 Document Type: Article Affiliation country: Aaem.v10i1.1507

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study / Randomized controlled trials Language: English Journal: Arch Acad Emerg Med Year: 2022 Document Type: Article Affiliation country: Aaem.v10i1.1507