Difference in Amyloid Load Between Single Memory Domain and Multidomain Subjective Cognitive Decline: A Study from the SILCODE.
J Alzheimers Dis
; 85(4): 1573-1582, 2022.
Article
in English
| MEDLINE | ID: covidwho-1745159
ABSTRACT
BACKGROUND:
Subjective cognitive decline (SCD), an at-risk condition of Alzheimer's disease (AD), can involve various cognitive domains, such as memory, language, planning, and attention.OBJECTIVE:
We aim to explore the difference in amyloid load between the single memory domain SCD (sd-SCD) and the multidomain SCD (md-SCD) and assess the relationship of amyloid pathology with quantitative SCD scores and objective cognition.METHODS:
A total of 63 SCD participants from the SILCODE study underwent the clinical evaluation, neuropsychological assessment, and 18F-florbetapir PET scan. Global amyloid standard uptake value ratio (SUVr) was calculated. Additionally, regional amyloid SUVr was quantified in 12 brain regions of interests. A nonparametric rank ANCOVA was used to compare the global and regional amyloid SUVr between the md-SCD (nâ=â34) and sd-SCD (nâ=â29) groups. A multiple linear regression analysis was conducted to test the relationship of amyloid SUVr with quantitative SCD scores and objective cognition.RESULTS:
Compared with individuals with sd-SCD, individuals with md-SCD had increased global amyloid SUVr (Fâ=â5.033, pâ=â0.029) and regional amyloid SUVr in the left middle temporal gyrus (Fâ=â12.309, pâ=â0.001; Bonferroni corrected), after controlling for the effects of age, sex, and education. When pooling all SCD participants together, the increased global amyloid SUVr was related with higher SCD-plus sum scores and lower Auditory Verbal Learning Test-delayed recall scores.CONCLUSION:
According to our findings, individuals with md-SCD showed higher amyloid accumulation than individuals with sd-SCD, suggesting that md-SCD may experience a more advanced stage of SCD. Additionally, increased global amyloid load was predictive of a poorer episodic memory function in SCD individuals.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Cognitive Dysfunction
/
Amyloid
Type of study:
Experimental Studies
/
Prognostic study
/
Randomized controlled trials
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
J Alzheimers Dis
Journal subject:
Geriatrics
/
Neurology
Year:
2022
Document Type:
Article
Affiliation country:
Jad-215373
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