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Humoral and Cellular Responses to SARS-CoV-2 in Convalescent COVID-19 Patients With Multiple Sclerosis.
Zabalza, Ana; Arrambide, Georgina; Tagliani, Paula; Cárdenas-Robledo, Simón; Otero-Romero, Susana; Esperalba, Juliana; Fernandez-Naval, Candela; Trocoli Campuzano, Jesus; Martínez Gallo, Mónica; Castillo, Mireia; Bonastre, Mercè; Resina Sallés, Mireia; Beltran, Jordina; Carbonell-Mirabent, Pere; Rodríguez-Barranco, Marta; López-Maza, Samuel; Melgarejo Otálora, Pedro José; Ruiz-Ortiz, Mariano; Pappolla, Agustin; Rodríguez Acevedo, Breogán; Midaglia, Luciana; Vidal-Jordana, Angela; Cobo-Calvo, Alvaro; Tur, Carmen; Galán, Ingrid; Castilló, Joaquín; Río, Jordi; Espejo, Carmen; Comabella, Manuel; Nos, Carlos; Sastre-Garriga, Jaume; Tintore, Mar; Montalban, Xavier.
  • Zabalza A; From the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Depar
  • Arrambide G; From the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Depar
  • Tagliani P; From the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Depar
  • Cárdenas-Robledo S; From the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Depar
  • Otero-Romero S; From the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Depar
  • Esperalba J; From the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Depar
  • Fernandez-Naval C; From the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Depar
  • Trocoli Campuzano J; From the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Depar
  • Martínez Gallo M; From the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Depar
  • Castillo M; From the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Depar
  • Bonastre M; From the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Depar
  • Resina Sallés M; From the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Depar
  • Beltran J; From the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Depar
  • Carbonell-Mirabent P; From the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Depar
  • Rodríguez-Barranco M; From the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Depar
  • López-Maza S; From the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Depar
  • Melgarejo Otálora PJ; From the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Depar
  • Ruiz-Ortiz M; From the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Depar
  • Pappolla A; From the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Depar
  • Rodríguez Acevedo B; From the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Depar
  • Midaglia L; From the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Depar
  • Vidal-Jordana A; From the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Depar
  • Cobo-Calvo A; From the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Depar
  • Tur C; From the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Depar
  • Galán I; From the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Depar
  • Castilló J; From the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Depar
  • Río J; From the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Depar
  • Espejo C; From the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Depar
  • Comabella M; From the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Depar
  • Nos C; From the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Depar
  • Sastre-Garriga J; From the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Depar
  • Tintore M; From the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Depar
  • Montalban X; From the Servei de Neurologia-Neuroimmunologia (A.Z., G.A., P.T., S.C.-R., S.O.-R., M. Castillo, M.B., M.R.S., J.B., P.C.-M., M.R.-B., S.L.-M., A.P., B.R.A., L.M., A.V.-J., A.C.-C., C.T., I.G., J.C., J.R., C.E., M. Comabella, C.N., J.S.-G., M.T., X.M.), and Preventive Medicine and Epidemiology Depar
Neurol Neuroimmunol Neuroinflamm ; 9(2)2022 03.
Article in English | MEDLINE | ID: covidwho-1745397
ABSTRACT
BACKGROUND AND

OBJECTIVES:

Information about humoral and cellular responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and antibody persistence in convalescent (COVID-19) patients with multiple sclerosis (PwMS) is scarce. The objectives of this study were to investigate factors influencing humoral and cellular responses to SARS-CoV-2 and its persistence in convalescent COVID-19 PwMS.

METHODS:

This is a retrospective study of confirmed COVID-19 convalescent PwMS identified between February 2020 and May 2021 by SARS-CoV-2 antibody testing. We examined relationships between demographics, MS characteristics, disease-modifying therapy (DMT), and humoral (immunoglobulin G against spike and nucleocapsid proteins) and cellular (interferon-gamma [IFN-γ]) responses to SARS-CoV-2.

RESULTS:

A total of 121 (83.45%) of 145 PwMS were seropositive, and 25/42 (59.5%) presented a cellular response up to 13.1 months after COVID-19. Anti-CD20-treated patients had lower antibody titers than those under other DMTs (p < 0.001), but severe COVID-19 and a longer time from last infusion increased the likelihood of producing a humoral response. IFN-γ levels did not differ among DMT. Five of 7 (71.4%) anti--CD20-treated seronegative patients had a cellular response. The humoral response persisted for more than 6 months in 41/56(81.13%) PwMS. In multivariate analysis, seropositivity decreased due to anti-CD20 therapy (OR 0.08 [95% CI 0.01-0.55]) and increased in males (OR 3.59 [1.02-12.68]), whereas the cellular response decreased in those with progressive disease (OR 0.04 [0.001-0.88]). No factors were associated with antibody persistence.

DISCUSSION:

Humoral and cellular responses to SARS-CoV-2 are present in COVID-19 convalescent PwMS up to 13.10 months after COVID-19. The humoral response decreases under anti-CD20 treatment, although the cellular response can be detected in anti-CD20-treated patients, even in the absence of antibodies.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunity, Humoral / COVID-19 / Immunity, Cellular / Multiple Sclerosis Type of study: Observational study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunity, Humoral / COVID-19 / Immunity, Cellular / Multiple Sclerosis Type of study: Observational study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Year: 2022 Document Type: Article