Detection techniques for epitranscriptomic marks.
Am J Physiol Cell Physiol
; 322(4): C787-C793, 2022 04 01.
Article
in English
| MEDLINE | ID: covidwho-1807579
ABSTRACT
Similar to epigenetic DNA modification, RNA can be methylated and altered for stability and processing. RNA modifications, namely, epitranscriptomes, involve the following three functions writing, erasing, and reading of marks. Methods for measurement and position detection are useful for the assessment of cellular function and human disease biomarkers. After pyrimidine 5-methylcytosine was reported for the first time a hundred years ago, numerous techniques have been developed for studying nucleotide modifications, including RNAs. Recent studies have focused on high-throughput and direct measurements for investigating the precise function of epitranscriptomes, including the characterization of severe acute respiratory syndrome coronavirus 2. The current study presents an overview of the development of detection techniques for epitranscriptomic marks and briefs about the recent progress in this field.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Transcriptome
/
COVID-19
Limits:
Humans
Language:
English
Journal:
Am J Physiol Cell Physiol
Journal subject:
Physiology
Year:
2022
Document Type:
Article
Affiliation country:
Ajpcell.00460.2021
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