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Specific changes of erythroid regulators and hepcidin in patients infected by SARS-COV-2.
Delaye, Jean-Baptiste; Alarcan, Hugo; Vallet, Nicolas; Veyrat-Durebex, Charlotte; Bernard, Louis; Hérault, Olivier; Ropert, Martine; Marlet, Julien; Gyan, Emmanuel; Andres, Christian; Blasco, Hélène; Piver, Eric.
  • Delaye JB; Service de Biochimie et Biologie Moléculaire, CHRU Tours, Tours, France J.DELAYE@chu-tours.fr.
  • Alarcan H; Service de Biochimie et Biologie Moléculaire, CHRU Tours, Tours, France.
  • Vallet N; Service d'Hématologie et thérapie cellulaire, CHRU Tours, Tours, France.
  • Veyrat-Durebex C; Service de Biochimie et Biologie Moléculaire, CHRU Tours, Tours, France.
  • Bernard L; UMR 1253, iBrain, Université de Tours, Tours, France.
  • Hérault O; Service de Médecine Interne et Maladies Infectieuses, CHRU Tours, Tours, France.
  • Ropert M; Service d'Hématologie biologique, CHRU Tours, Tours, France.
  • Marlet J; CNRS ERL7001 LNOX, EA 3549, Université de Tours, Tours, France.
  • Gyan E; Service de Biochimie, CHU Rennes, Rennes, France.
  • Andres C; INSERM U1259, MAVIVH, Université de Tours, Tours, France.
  • Blasco H; Service de bactériologie-virologie-hygiène, CHRU Tours, Tours, France.
  • Piver E; Service d'Hématologie et thérapie cellulaire, CHRU Tours, Tours, France.
J Investig Med ; 70(4): 934-938, 2022 04.
Article in English | MEDLINE | ID: covidwho-1745675
ABSTRACT
Iron metabolism is tightly linked to infectious and inflammatory signals through hepcidin synthesis. To date, iron homeostasis during SARS-CoV-2 infection has not yet been described. The aim of this study is to characterize the hepcidin and erythroid regulators (growth differentiation factor 15 (GDF-15) and erythroferrone (ERFE)) by measuring concentrations in plasma in context of COVID-19 disease.We performed a single-center observational study of patients with COVID-19 to evaluate concentrations of main regulatory proteins involved in iron homeostasis, namely hepcidin, ERFE and GDF-15. SARS-CoV-2 infection (COVID-19+) was defined by a positive RT-PCR. Sixteen patients with COVID-19+ were gender-matched and age-matched to 16 patients with a sepsis unrelated to SARS-CoV-2 (COVID-19-) and were compared with non-parametric statistic test.Clinical and hematological parameters, plasma iron, transferrin, transferrin saturation, ferritin, soluble transferrin receptor and C reactive protein were not statistically different between both groups. Median plasma hepcidin concentrations were higher in the COVID-19+ group (44.1 (IQR 16.55-70.48) vs 14.2 (IQR 5.95-18.98) nmol/L, p=0.003), while median ERFE and GDF-15 concentrations were lower in the COVID-19+ group (0.16 (IQR 0.01-0.73) vs 0.89 (IQR 0.19-3.82) ng/mL, p=0.035; 2003 (IQR 1355-2447) vs 4713 (IQR 2082-7774) pg/mL, p=0015), respectively) compared with the COVID-19- group.This is the first study reporting lower ERFE and GDF-15 median concentrations in patients with COVID-19+ compared with patients with COVID-19-, associated with an increased median concentration of hepcidin in the COVID-19+ group compared with COVID19- group.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Hepcidins / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: J Investig Med Journal subject: Medicine Year: 2022 Document Type: Article Affiliation country: Jim-2021-002270

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Hepcidins / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: J Investig Med Journal subject: Medicine Year: 2022 Document Type: Article Affiliation country: Jim-2021-002270