Prenatal alcohol and cannabis exposure can have opposing and region-specific effects on parvalbumin interneuron numbers in the hippocampus.
Alcohol Clin Exp Res
; 45(11): 2246-2255, 2021 11.
Article
in English
| MEDLINE | ID: covidwho-1745994
ABSTRACT
BACKGROUND:
We recently showed that alcohol and cannabis can interact prenatally, and in a recent review paper, we identified parvalbumin-positive (PV) interneurons in the hippocampus as a potential point of convergence for these teratogens.METHODS:
A 2 (Ethanol [EtOH], Air) × 2 (tetrahydrocannabinol [THC], Vehicle) design was used to expose pregnant Sprague-Dawley rats to either EtOH or air, in addition to either THC or the inhalant vehicle solution, during gestational days 5-20. Immunohistochemistry was performed to detect PV interneurons in 1 male and 1 female pup from each litter at postnatal day 70.RESULTS:
Significant between-group and subregion-specific effects were found in the dorsal cornu ammonis 1 (CA1) subfield and the ventral dentate gyrus (DG). In the dorsal CA1 subfield, there was an increase in the number of PV interneurons in both the EtOH and EtOH +THC groups, but a decrease with THC alone. There were fewer changes in interneuron numbers overall in the DG, though there was a sex difference, with a decrease in the number of PV interneurons in the THC-exposed group in males. There was also a greater cell layer volume in the DG in the EtOH +THC group than the control group, and in the CA1 region in the EtOH group compared to the control and THC groups.CONCLUSIONS:
Prenatal exposure to alcohol and THC differentially affects parvalbumin-positive interneuron numbers in the hippocampus, indicating that both individual and combined exposure can impact the balance of excitation and inhibition in a structure critically involved in learning and memory processes.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Parvalbumins
/
Prenatal Exposure Delayed Effects
/
Cannabinoid Receptor Agonists
/
Hippocampus
/
Interneurons
Type of study:
Experimental Studies
/
Randomized controlled trials
Limits:
Animals
/
Pregnancy
Language:
English
Journal:
Alcohol Clin Exp Res
Year:
2021
Document Type:
Article
Affiliation country:
Acer.14708
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