Cholecystitis as a Possible Immunologic Consequence of COVID-19;Case Series from a Large Healthcare System
Open Forum Infectious Diseases
; 8(SUPPL 1):S258-S259, 2021.
Article
in English
| EMBASE | ID: covidwho-1746688
ABSTRACT
Background. Gastrointestinal manifestations are commonly seen in COVID-19 disease with up to 50% of patients reporting nausea or diarrhea. Cholecystitis has been described in rare cases related to COVID-19, possibly in consequence of immune activation, but biliary disease from SARS-CoV-2 infection is not well described. We examined a case series of patients with both COVID-19 and cholecystitis at our institution. Methods. We performed a retrospective chart review of all patients with a diagnosis of cholecystitis within 3 months of SARS-CoV-2 infection;looking at clinical, laboratory, and radiographic characteristics of this population. Results. 30 individuals were identified with a diagnosis of cholecystitis within 3 months of diagnosis of SARS-CoV-2 infection. Most patients presenting with cholecystitis were female and obese (see Table 1). 14 individuals were diagnosed with SARSCoV-2 infection during the same presentation as their cholecystitis diagnosis, usually as part of pre-operative screening. Of 16 individuals diagnosed with SARS-CoV-2 prior to their cholecystitis presentation, a mean of 24 and 17 days elapsed between SARS-CoV-2 infection and cholecystitis symptom onset and radiographic diagnosis, respectively (see Figure 1). Most of these patients had mild respiratory disease, with only 9 developing an oxygen requirement, and only 3 requiring mechanical ventilation. While 17 patients were treated surgically for their cholecystitis, this did not appear to impact symptom resolution. Conclusion. Cholecystitis may be an uncommon complication of COVID-19 disease. Cholecystitis may manifest most often 2-4 weeks following SARS-CoV-2 infection. This timing is similar to that in Multisystem Inflammatory Syndrome following SARS-CoV-2 infection and given similarities in timing to we hypothesize that cholecystitis in our patients could be driven by immune activation.
oxygen; adult; artificial ventilation; case report; case study; cholecystitis; clinical article; clinical laboratory; complication; conference abstract; coronavirus disease 2019; diagnosis; diarrhea; female; health care system; human; immunostimulation; medical record review; nausea; nonhuman; obesity; preoperative evaluation; radiodiagnosis; respiratory tract disease; retrospective study; Severe acute respiratory syndrome coronavirus 2; surgery; systemic inflammatory response syndrome
Full text:
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Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
Open Forum Infectious Diseases
Year:
2021
Document Type:
Article
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