Clinical Features of and Risk Factors for 30-day Readmission after an Initial Hospitalization with COVID-19
Open Forum Infectious Diseases
; 8(SUPPL 1):S26-S27, 2021.
Article
in English
| EMBASE | ID: covidwho-1746803
ABSTRACT
Background. Little is known about risk factors for readmission after COVID-19 hospitalizations. Knowledge of these factors may help to identify patients at increased risk and may help to prevent these rehospitalizations. Methods. This historical cohort study was conducted at a tertiary care academic medical center. We included COVID-19 cases diagnosed by reverse-transcriptase polymerase-chain-reaction (RT-PCR) assay between March 8th and June 14th, 2020. Patients readmitted within 30 days were identified. Using the electronic medical record, we collected data on demographic and clinical information. Data were analyzed using Student's t-test, the chi-squared test and multivariable logistic regression. Results. We included 391 patients who survived after the index hospitalization for COVID-19. The readmission rate was 13.3% (52/391). The mean time to readmission was 9.2 ± 7.9 days. The mean age (±SD) was 66.3 ± 18.6 years, 44.2% were male, and 78.8% were black/African-American. The most common presenting complaint was shortness of breath (50%). The most frequent diagnosis during the readmission was infectious process (57.7%). The mortality rate on readmission was 11.5%. Patients with a 30-day readmission were older than those not readmitted, mean age (±SD) 66.3 ± 18.6 vs. 61.0 ± 16.0, respectively (p=0.03). Readmitted patients also had a higher prevalence of heart failure and renal disease as comorbidities. Elevated alanine aminotransferase (AST) and low albumin level were also associated with readmission (Table 1). Intensive care unit (ICU) admission or mechanical ventilation during the index admission did not increase the risk of readmission. From multivariable analysis, independent predictors of 30-day readmission were higher Charlson score (p=0.004), higher creatinine on admission in the index hospitalization (p=0.009), and presence of rhabdomyolysis during the index hospitalization (p=0.039) (Table 2). Table 2. Multivariable Analysis of Predictors for Readmission within 30 days from COVID-19 Infection Conclusion. In our cohort, infectious etiologies were common among those readmitted within 30 days of COVID-19. A higher Charlson score, acute renal failure, and rhabdomyolysis during the index admission were independent predictors of a 30-day readmission. Further studies are required to investigate these contributing factors.
alanine aminotransferase; creatinine; endogenous compound; acute kidney failure; African American; aged; albumin level; artificial ventilation; aspartate aminotransferase level; clinical feature; cohort analysis; comorbidity; conference abstract; controlled study; coronavirus disease 2019; demography; dyspnea; electronic medical record; female; heart failure; hospital readmission; hospitalization; human; intensive care unit; kidney disease; major clinical study; male; mortality rate; prevalence; reverse transcription polymerase chain reaction; rhabdomyolysis; risk factor; tertiary health care; university hospital
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Prognostic study
Language:
English
Journal:
Open Forum Infectious Diseases
Year:
2021
Document Type:
Article
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