Neuraminidase inhibitor treatment is associated with decreased mortality in COVID-19 patients: a retrospective analysis.
Eur Heart J Cardiovasc Pharmacother
; 8(4): 392-401, 2022 06 08.
Article
in English
| MEDLINE | ID: covidwho-1746904
ABSTRACT
AIMS:
The aim of this study was to investigate the effects of Neuraminidase inhibitors (NI) on COVID-19 in a retrospective study. METHODS ANDRESULTS:
The study included an overall COVID-19 patients (n = 3267) and a 11 propensity score-matched patients (n = 972). The levels of plasma N-acetylneuraminic acid and neuraminidase expression were further evaluated in a panel of hospitalized and 1-month post-infection recovered COVID-19 subjects. The mortality rate in the overall patients was 9.6% (313/3267) and 9.2% (89/972) in the propensity-score matched patients. The NI treatment lowered the mortality rate (5.7% vs. 10.3%) and the critically ill conversion rate (14.1% vs. 19.7%) compare to those in the non-NI group in the overall patients and evaluated in the propensity score-matched patients when applying the multivariate Cox model for adjusting imbalanced confounding factors. Furthermore, NI treatment was associated with attenuated cytokine storm levels and acute heart injury but not liver or kidney injuries. Further analysis in a small panel of patients found the levels of N-acetylneuraminic acid and neuraminidase (dominantly the NEU3 isoform) were elevated in the hospitalized COVID-19 subjects and recovered at the 1-month post-infection stage, suggesting increasing desialylation in COVID-19 patients.CONCLUSION:
These results suggest that NI treatment is associated with decreased mortality in COVID-19 subjects, especially for those subjects with acute heart injury.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
COVID-19
/
COVID-19 Drug Treatment
/
Neuraminidase
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Eur Heart J Cardiovasc Pharmacother
Year:
2022
Document Type:
Article
Affiliation country:
Ehjcvp
Similar
MEDLINE
...
LILACS
LIS