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BCG vaccination strategies against tuberculosis: updates and perspectives.
Qu, Mengjin; Zhou, Xiangmei; Li, Hao.
  • Qu M; College of Veterinary Medicine, China Agricultural University, Beijing, China.
  • Zhou X; Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, China Agricultural University, Beijing, China.
  • Li H; College of Veterinary Medicine, China Agricultural University, Beijing, China.
Hum Vaccin Immunother ; 17(12): 5284-5295, 2021 12 02.
Article in English | MEDLINE | ID: covidwho-1746993
ABSTRACT
Bacillus Calmette-Guérin (BCG) is the only licensed vaccine against tuberculosis (TB). However, BCG has variable efficacy and cannot completely prevent TB infection and transmission. Therefore, the worldwide prevalence of TB calls for urgent development of a more effective TB vaccine. In the absence of other approved vaccines, it is also necessary to improve the efficacy of BCG itself. Intravenous (IV) BCG administration and BCG revaccination strategies have recently shown promising results for clinical usage. Therefore, it is necessary for us to revisit the BCG vaccination strategies and summarize the current research updates related to BCG vaccination. This literature review provides an updated overview and perspectives of the immunization strategies against TB using BCG, which may inspire the following research on TB vaccine development.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Tuberculosis / Tuberculosis Vaccines / Mycobacterium bovis / Mycobacterium tuberculosis Type of study: Observational study / Prognostic study / Reviews Topics: Vaccines Limits: Humans Language: English Journal: Hum Vaccin Immunother Year: 2021 Document Type: Article Affiliation country: 21645515.2021.2007711

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Tuberculosis / Tuberculosis Vaccines / Mycobacterium bovis / Mycobacterium tuberculosis Type of study: Observational study / Prognostic study / Reviews Topics: Vaccines Limits: Humans Language: English Journal: Hum Vaccin Immunother Year: 2021 Document Type: Article Affiliation country: 21645515.2021.2007711