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The importance of neopterin in COVID-19: The prognostic value and relation with the disease severity.
Rasmi, Yousef; Heidari, Nadia; Kübra Kirboga, Kevser; Hatamkhani, Shima; Tekin, Burcu; Alipour, Shahryar; Naderi, Roya; Farnamian, Yeghaneh; Akca, Ilknur.
  • Rasmi Y; Cellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran; Department of Biochemistry, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
  • Heidari N; Department of Biochemistry, School of Medicine, Gorgan University of Medical Sciences, Urmia, Iran.
  • Kübra Kirboga K; Suleyman Demirel University, Bioengineering Department, Isparta 32260, Turkey.
  • Hatamkhani S; Experimental and Applied Pharmaceutical Sciences Research Center, Department of Clinical Pharmacy, School of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran.
  • Tekin B; Izmir Institute of Technology, Biotechnology Department, Izmir, Turkey.
  • Alipour S; Department of Biochemistry and Applied Cell, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
  • Naderi R; Department of Physiology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
  • Farnamian Y; Student Research Center, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
  • Akca I; Mersin University, Faculty of Sciences, Department of Biotechnology, Mersin, Turkey.
Clin Biochem ; 104: 1-12, 2022 Jun.
Article in English | MEDLINE | ID: covidwho-1748124
ABSTRACT
Coronavirus Disease 2019 [COVID-19], caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2], has rapidly evolved into a global health emergency. Neopterin [NPT], produced by macrophages when stimulated with interferon [IFN-]gamma, is an essential cytokine in the antiviral immune response. NPT has been used as a marker for the early assessment of disease severity in different diseases. The leading cause of NPT production is the pro-inflammatory cytokine IFN-. Macrophage activation has also been revealed to be linked with disease severity in SARS-CoV-2 patients. We demonstrate the importance of NPT in the pathogenesis of SARS-CoV-2 and suggest that targeting NPT in SARS-CoV-2 infection may be critical in the early prediction of disease progression and provision of timely management of infected individuals.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Neopterin / COVID-19 Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: Clin Biochem Year: 2022 Document Type: Article Affiliation country: J.clinbiochem.2022.03.002

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Neopterin / COVID-19 Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: Clin Biochem Year: 2022 Document Type: Article Affiliation country: J.clinbiochem.2022.03.002