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Frailty as a predictor of mortality in COVID-19 patients receiving CPAP for respiratory insufficiency.
Damanti, Sarah; Ramirez, Giuseppe Alvise; Bozzolo, Enrica Paola; Da Prat, Valentina; Di Lucca, Giuseppe; Di Terlizzi, Gaetano; Marinosci, Alessandro; Scotti, Raffaella; Strada, Silvia; Scarpellini, Paolo; Castiglioni, Barbara; Oltolini, Chiara; Ripa, Marco; Din, Chiara Tassan; Centurioni, Clarissa Elisabeth; Di Scala, Flavia; Gobbi, Agnese; Alba, Ada Carla; Casiraghi, Giuseppina Maria; Morgillo, Anna; Tresoldi, Moreno.
  • Damanti S; Unit of General Medicine and Advanced Care, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, Italy. damanti.sarah@hotmail.it.
  • Ramirez GA; Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Bozzolo EP; Unit of General Medicine and Advanced Care, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, Italy.
  • Da Prat V; Unit of General Medicine and Advanced Care, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, Italy.
  • Di Lucca G; Unit of General Medicine and Advanced Care, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, Italy.
  • Di Terlizzi G; Unit of General Medicine and Advanced Care, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, Italy.
  • Marinosci A; Unit of General Medicine and Advanced Care, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, Italy.
  • Scotti R; Unit of General Medicine and Advanced Care, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, Italy.
  • Strada S; Unit of General Medicine and Advanced Care, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, Italy.
  • Scarpellini P; Unit of Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Castiglioni B; Unit of Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Oltolini C; Unit of Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Ripa M; Unit of Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Din CT; Unit of Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Centurioni CE; Unit of General Medicine and Advanced Care, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, Italy.
  • Di Scala F; Vita-Salute San Raffaele University, Milan, Italy.
  • Gobbi A; Unit of General Medicine and Advanced Care, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, Italy.
  • Alba AC; Vita-Salute San Raffaele University, Milan, Italy.
  • Casiraghi GM; Unit of General Medicine and Advanced Care, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, Italy.
  • Morgillo A; Vita-Salute San Raffaele University, Milan, Italy.
  • Tresoldi M; Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Aging Clin Exp Res ; 34(4): 945-949, 2022 Apr.
Article in English | MEDLINE | ID: covidwho-1748379
ABSTRACT

OBJECTIVE:

Exploring the association between frailty and mortality in a cohort of patients with COVID-19 respiratory insufficiency treated with continuous positive airway pressure.

METHODS:

Frailty was measured using a Frailty Index (FI) created by using the baseline assessment data on comorbidities and body mass index and baseline blood test results (including pH, lactate dehydrogenase, renal and liver function, inflammatory indexes and anemia). FI > 0.25 identified frail individuals.

RESULTS:

Among the 159 included individuals (81% men, median age of 68) frailty was detected in 69% of the patients (median FI score 0.3 ± 0.08). Frailty was associated to an increased mortality (adjusted HR 1.99, 95% CI 1.02-3.88, p = 0.04).

CONCLUSIONS:

Frailty is highly prevalent among patients with COVID-19, predicts poorer outcomes independently of age. A personalization of care balancing the risk and benefit of treatments (especially the invasive ones) in such complex patients is pivotal.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Insufficiency / Frailty / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Aged / Female / Humans / Male Language: English Journal: Aging Clin Exp Res Journal subject: Geriatrics Year: 2022 Document Type: Article Affiliation country: S40520-021-02070-z

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Insufficiency / Frailty / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Aged / Female / Humans / Male Language: English Journal: Aging Clin Exp Res Journal subject: Geriatrics Year: 2022 Document Type: Article Affiliation country: S40520-021-02070-z