Your browser doesn't support javascript.
D614G mutation and SARS-CoV-2: impact on S-protein structure, function, infectivity, and immunity.
Bhattacharya, Manojit; Chatterjee, Srijan; Sharma, Ashish Ranjan; Agoramoorthy, Govindasamy; Chakraborty, Chiranjib.
  • Bhattacharya M; Department of Zoology, Fakir Mohan University, Vyasa Vihar, Balasore, 756020, Odisha, India.
  • Chatterjee S; Department of Biotechnology, School of Life Science and Biotechnology, Adamas University, Barasat-Barrackpore Rd, Kolkata, West Bengal, 700126, India.
  • Sharma AR; Institute for Skeletal Aging and Orthopaedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, 24252, Gangwon-do, Republic of Korea.
  • Agoramoorthy G; College of Pharmacy and Health Care, Tajen University, Yanpu, Pingtung, 907, Taiwan. agoram@tajen.edu.tw.
  • Chakraborty C; Department of Biotechnology, School of Life Science and Biotechnology, Adamas University, Barasat-Barrackpore Rd, Kolkata, West Bengal, 700126, India. drchiranjib@yahoo.com.
Appl Microbiol Biotechnol ; 105(24): 9035-9045, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1748501
ABSTRACT
The progression of the COVID-19 pandemic has generated numerous emerging variants of SARS-CoV-2 on a global scale. These variants have gained evolutionary advantages, comprising high virulence and serious infectivity due to multiple spike glycoprotein mutations. As a reason, variants are demonstrating significant abilities to escape the immune responses of the host. The D614G mutation in the S-glycoprotein of SARS-CoV-2 variants has shown the most efficient interaction with the ACE2 receptor of the cells. This explicit mutation at amino acid position 614 (aspartic acid-to-glycine substitution) is the prime cause of infection and re-infection. It changes the conformation of RBD and cleavage patterns S-glycoprotein with higher stability, replication fitness, and fusion efficiencies. Therefore, this review aims to provide several crucial pieces of information associated with the D614 mutational occurrence of SARS-CoV-2 variants and their infectivity patterns. This review will also effectively emphasize the mechanism of action of D614G mutant variants, immune escape, and partial vaccine escape of this virus. Furthermore, the viral characteristic changes leading to the current global pandemic condition have been highlighted. Here, we have tried to illustrate a novel direction for future researchers to develop effective therapeutic approaches and counterweight strategies to minimize the spread of COVID-19.Key points• D614G mutation arises within the S-glycoprotein of significant SARS-CoV-2 variants.• The D614G mutation affects infection, re-infection, cleavage patterns of S-glycoprotein, and replication fitness of SARS-CoV-2 variants.• The D614G mutation influences the immunity and partial vaccine escape.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies Topics: Vaccines / Variants Limits: Humans Language: English Journal: Appl Microbiol Biotechnol Year: 2021 Document Type: Article Affiliation country: S00253-021-11676-2

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies Topics: Vaccines / Variants Limits: Humans Language: English Journal: Appl Microbiol Biotechnol Year: 2021 Document Type: Article Affiliation country: S00253-021-11676-2