Pandemic vaccine testing: Combining conventional and challenge studies.

Gerhard, Tobias; Strom, Brian L; Eyal, Nir

Gerhard, Tobias; Strom, Brian L; Eyal, Nir.

Gerhard T; Center for Pharmacoepidemiology and Treatment Science, Rutgers University, New Brunswick, New Jersey, USA.
Strom BL; Ernest Mario School of Pharmacy, Rutgers University, Piscataway, New Jersey, USA.
Eyal N; Center for Pharmacoepidemiology and Treatment Science, Rutgers University, New Brunswick, New Jersey, USA.

Pharmacoepidemiol Drug Saf ; 31(6): 710-715, 2022 06.

Article in English | MEDLINE | ID: covidwho-1748605

ABSTRACT

ABSTRACT

Early into COVID, human challenge trials were considered, but usually as alternatives to conventional randomized controlled trials. Instead, assessment of authorized COVID vaccines, of further COVID vaccines, and of vaccines against future pandemics should combine both designs, in five different ways, including a wholly novel one that we elaborate, Viz., combining data from both designs to answer a single question.

Subject(s)

COVID-19; Vaccines; COVID-19/epidemiology; COVID-19/prevention & control; COVID-19 Vaccines; Humans; Pandemics/prevention & control; SARS-CoV-2

Keywords

adaptive clinical trials as topic; coronavirus; ethics; randomized controlled trials as topic; vaccines

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines / COVID-19 Type of study: Experimental Studies / Observational study / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: Pharmacoepidemiol Drug Saf Journal subject: Epidemiology / Drug Therapy Year: 2022 Document Type: Article Affiliation country: Pds.5429

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