Evaluation of safety of using incompatible plasma for therapeutic plasma exchange during shortage of AB plasma.
J Clin Apher
; 36(4): 628-633, 2021 Aug.
Article
in English
| MEDLINE | ID: covidwho-1748739
ABSTRACT
BACKGROUND:
Criteria for selection of FFP blood type has not been clearly established and use of group AB plasma is preferred by numerous transplantation protocols.AIMS:
This study assesses the safety and efficacy of alternative group A or B plasma in ABO incompatible solid organ transplantation. MATERIALS &METHODS:
Alternative use of group A or B plasma (incompatible plasma) was inevitable during the shortage of group AB plasma. Experience from select number of patients during the period of extreme group AB plasma shortage is described.RESULTS:
The result of alternative use of group A or B plasma was within expectation, showing effective reduction of isoagglutinin titers for pre-operative desensitization and efficacy for treatment of post-operative patients. No immediate hemolytic transfusion reaction was reported.DISCUSSION:
While validation in a larger cohort of patients is necessary, our limited experience have shown satisfactory clinical outcomes without adverse events.CONCLUSIONS:
Use of incompatible group A or B plasma is a viable option when group AB plasma is limited.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Plasma Exchange
/
Transplantation
/
Blood Group Incompatibility
/
ABO Blood-Group System
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Limits:
Humans
Language:
English
Journal:
J Clin Apher
Year:
2021
Document Type:
Article
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