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Infection fatality rate of COVID-19 in community-dwelling elderly populations.
Axfors, Cathrine; Ioannidis, John P A.
  • Axfors C; Meta-Research Innovation Center at Stanford (METRICS), Stanford University, Stanford, CA, USA.
  • Ioannidis JPA; Meta-Research Innovation Center at Stanford (METRICS), Stanford University, Stanford, CA, USA. jioannid@stanford.edu.
Eur J Epidemiol ; 37(3): 235-249, 2022 Mar.
Article in English | MEDLINE | ID: covidwho-1750758
ABSTRACT
This mixed design synthesis aimed to estimate the infection fatality rate (IFR) of Coronavirus Disease 2019 (COVID-19) in community-dwelling elderly populations and other age groups from seroprevalence studies. Protocol https//osf.io/47cgb . Eligible were seroprevalence studies done in 2020 and identified by any of four existing systematic reviews; with ≥ 500 participants aged ≥ 70 years; presenting seroprevalence in elderly people; aimed to generate samples reflecting the general population; and whose location had available data on cumulative COVID-19 deaths in elderly (primary cutoff ≥ 70 years; ≥ 65 or ≥ 60 also eligible). We extracted the most fully adjusted (if unavailable, unadjusted) seroprevalence estimates; age- and residence-stratified cumulative COVID-19 deaths (until 1 week after the seroprevalence sampling midpoint) from official reports; and population statistics, to calculate IFRs adjusted for test performance. Sample size-weighted IFRs were estimated for countries with multiple estimates. Thirteen seroprevalence surveys representing 11 high-income countries were included in the main analysis. Median IFR in community-dwelling elderly and elderly overall was 2.9% (range 1.8-9.7%) and 4.5% (range 2.5-16.7%) without accounting for seroreversion (2.2% and 4.0%, respectively, accounting for 5% monthly seroreversion). Multiple sensitivity analyses yielded similar results. IFR was higher with larger proportions of people > 85 years. The IFR of COVID-19 in community-dwelling elderly is lower than previously reported.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Observational study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Limits: Aged / Humans Language: English Journal: Eur J Epidemiol Journal subject: Epidemiology Year: 2022 Document Type: Article Affiliation country: S10654-022-00853-w

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Observational study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Limits: Aged / Humans Language: English Journal: Eur J Epidemiol Journal subject: Epidemiology Year: 2022 Document Type: Article Affiliation country: S10654-022-00853-w