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Burden of primary influenza and respiratory syncytial virus pneumonia in hospitalised adults: insights from a 2-year multi-centre cohort study (2017-2018).
Boattini, Matteo; Charrier, Lorena; Almeida, André; Christaki, Eirini; Moreira Marques, Torcato; Tosatto, Valentina; Bianco, Gabriele; Iannaccone, Marco; Tsiolakkis, Georgios; Karagiannis, Christos; Maikanti, Panagiota; Cruz, Lourenço; Antão, Diogo; Moreira, Maria Inês; Cavallo, Rossana; Costa, Cristina.
  • Boattini M; Microbiology and Virology Unit, University Hospital Città della Salute e della Scienza di Torino, Turin, Italy.
  • Charrier L; Department of Public Health and Paediatrics, University of Torino, Turin, Italy.
  • Almeida A; Department of Internal Medicine 4, Hospital de Santa Marta, Central Lisbon Hospital Centre, Lisbon, Portugal.
  • Christaki E; NOVA Medical School, Universidade Nova de Lisboa, Lisbon, Portugal.
  • Moreira Marques T; Medical School, University of Cyprus, Nicosia, Cyprus.
  • Tosatto V; Department of Medicine, Nicosia General Hospital, Nicosia, Cyprus.
  • Bianco G; Department of Internal Medicine 4, Hospital de Santa Marta, Central Lisbon Hospital Centre, Lisbon, Portugal.
  • Iannaccone M; Department of Internal Medicine 4, Hospital de Santa Marta, Central Lisbon Hospital Centre, Lisbon, Portugal.
  • Tsiolakkis G; NOVA Medical School, Universidade Nova de Lisboa, Lisbon, Portugal.
  • Karagiannis C; Microbiology and Virology Unit, University Hospital Città della Salute e della Scienza di Torino, Turin, Italy.
  • Maikanti P; Microbiology and Virology Unit, University Hospital Città della Salute e della Scienza di Torino, Turin, Italy.
  • Cruz L; Department of Medicine, Nicosia General Hospital, Nicosia, Cyprus.
  • Antão D; Department of Microbiology, Nicosia General Hospital, Nicosia, Cyprus.
  • Moreira MI; Department of Microbiology, Nicosia General Hospital, Nicosia, Cyprus.
  • Cavallo R; Department of Internal Medicine 4, Hospital de Santa Marta, Central Lisbon Hospital Centre, Lisbon, Portugal.
  • Costa C; Department of Internal Medicine 4, Hospital de Santa Marta, Central Lisbon Hospital Centre, Lisbon, Portugal.
Intern Med J ; 2021 Oct 11.
Article in English | MEDLINE | ID: covidwho-2252435
ABSTRACT

BACKGROUND:

Viral community-acquired pneumonia (CAP) is a potentially serious illness, particularly in adult patients with underlying chronic conditions. In addition to the most recent SARS-CoV-2, influenza, and respiratory syncytial virus (RSV) are considered the most relevant causes of viral CAP.

AIMS:

To describe the clinical features of hospitalised adults admitted for influenza-A/B and RSV pneumonia and analyse, according to aetiology, factors associated with non-invasive ventilation (NIV) failure and in-hospital death (IHD).

METHODS:

This was a retrospective and multi-centre study of all adults who were admitted for laboratory-confirmed influenza-A/B or RSV pneumonia, during two consecutive winter seasons (October-April 2017-2018 and 2018-2019) in three tertiary hospitals in Portugal, Italy and Cyprus.

RESULTS:

A total of 356 adults were included in the study. Influenza-A, influenza-B and RSV were deemed to cause pneumonia in 197 (55.3%), 85 (23.9%) and 74 (20.8%) patients, respectively. Patients with both obstructive sleep apnoea or obesity hypoventilation syndrome and influenza-A virus pneumonia showed a higher risk for NIV failure (odds ratio (OR) 4.66; 95% confidence interval (CI) 1.42-15.30). Patients submitted to NIV showed a higher risk for IHD, regardless of comorbidities (influenza-A OR 3.00; 95% CI 1.35-6.65, influenza-B OR 4.52; 95% CI 1.13-18.01, RSV OR 5.61; 95% CI 1.26-24.93).

CONCLUSION:

The increased knowledge of influenza-A/B and RSV pneumonia burden may contribute to a better management of patients with viral CAP.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Etiology study / Observational study / Prognostic study Language: English Journal subject: Internal Medicine Year: 2021 Document Type: Article Affiliation country: Imj.15583

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Etiology study / Observational study / Prognostic study Language: English Journal subject: Internal Medicine Year: 2021 Document Type: Article Affiliation country: Imj.15583