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Effect of the COVID-19 Lockdown on Asthma Biological Rhythms.
Hazan, Guy; Fox, Carolyn; Eiden, Elise; Anderson, Neil; Friger, Michael; Haspel, Jeffrey.
  • Hazan G; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Fox C; Division of Pediatric Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Eiden E; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Anderson N; Institute for Informatics, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Friger M; Division of Laboratory and Genomic Medicine, Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Haspel J; Department of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
J Biol Rhythms ; 37(2): 152-163, 2022 04.
Article in English | MEDLINE | ID: covidwho-1753024
ABSTRACT
Asthma has a striking temporal character, in which time-of-day, patient age, and season each influence disease activity. The extent to which rhythms in asthma activity reflect exposure to specific disease triggers remains unclear. In this study, we examined how virus mitigation strategies enacted during the COVID-19 pandemic ("lockdown measures") affected rhythms in asthma clinical activity in children. To this end, we retrospectively analyzed asthma clinical presentations in children aged <18 years to our regional academic medical center, comparing 4 years of medical records prior to COVID-19 lockdown measures with the 12 months immediately after the institution of such measures. We correlated these data to positive viral test results, febrile seizures, and allergic clinical surrogates (allergic reaction visits and Emergency Department [ED] antihistamine prescriptions, respectively) over the same time frame. In the 12 months following the institution of the COVID-19 lockdown, positivity rates for common respiratory viruses dropped by 70.2% and ED visits for asthma among children dropped by 62% compared to pre-COVID years. Lockdown suppressed seasonal variation in positive viral tests and asthma ED visits, while diurnal rhythms in asthma visits were unchanged. Asthma seasonality correlated most strongly with rhinovirus positivity both before and after the institution of COVID lockdown measures. Altogether, our data support a causal role for viruses in driving seasonal variability in asthma exacerbations in children.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Asthma / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Child / Humans Language: English Journal: J Biol Rhythms Journal subject: Physiology Year: 2022 Document Type: Article Affiliation country: 07487304221081730

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Asthma / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Child / Humans Language: English Journal: J Biol Rhythms Journal subject: Physiology Year: 2022 Document Type: Article Affiliation country: 07487304221081730