Evolution of 18F-FDG PET/CT Findings in Patients After COVID-19: An Initial Investigation.
J Nucl Med
; 63(2): 270-273, 2022 02.
Article
in English
| MEDLINE | ID: covidwho-1753320
ABSTRACT
The aim of this study was to assess the temporal evolution of pulmonary 18F-FDG uptake in patients with coronavirus disease 2019 (COVID-19) and post-COVID-19 lung disease (PCLD). Methods:
Using our hospital's clinical electronic records, we retrospectively identified 23 acute COVID-19, 18 PCLD, and 9 completely recovered 18F-FDG PET/CT patients during the 2 peaks of the U.K. pandemic. Pulmonary 18F-FDG uptake was measured as a lung target-to-background ratio (TBRlung = SUVmax/SUVmin) and compared with temporal stage.Results:
In acute COVID-19, less than 3 wk after infection, TBRlung was strongly correlated with time after infection (rs = 0.81, P < 0.001) and was significantly higher in the late stage than in the early stage (P = 0.001). In PCLD, TBRlung was lower in patients treated with high-dose steroids (P = 0.003) and in asymptomatic patients (P < 0.001).Conclusion:
Pulmonary 18F-FDG uptake in COVID-19 increases with time after infection. In PCLD, pulmonary 18F-FDG uptake rises despite viral clearance, suggesting ongoing inflammation. There was lower pulmonary 18F-FDG uptake in PCLD patients treated with steroids.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Radiopharmaceuticals
/
Fluorodeoxyglucose F18
/
Positron Emission Tomography Computed Tomography
/
SARS-CoV-2
/
COVID-19
/
Lung
Type of study:
Observational study
/
Prognostic study
Topics:
Long Covid
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
/
Young adult
Language:
English
Journal:
J Nucl Med
Year:
2022
Document Type:
Article
Affiliation country:
Jnumed.121.262296
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