Your browser doesn't support javascript.
A Case Series of Myocarditis Following Third (Booster) Dose of COVID-19 Vaccination: Magnetic Resonance Imaging Study.
Shiyovich, Arthur; Witberg, Guy; Aviv, Yaron; Kornowski, Ran; Hamdan, Ashraf.
  • Shiyovich A; Department of Cardiology, Rabin Medical Center, Tel Aviv University, Tel Aviv, Israel.
  • Witberg G; Department of Cardiology, Rabin Medical Center, Tel Aviv University, Tel Aviv, Israel.
  • Aviv Y; Department of Cardiology, Rabin Medical Center, Tel Aviv University, Tel Aviv, Israel.
  • Kornowski R; Department of Cardiology, Rabin Medical Center, Tel Aviv University, Tel Aviv, Israel.
  • Hamdan A; Department of Cardiology, Rabin Medical Center, Tel Aviv University, Tel Aviv, Israel.
Front Cardiovasc Med ; 9: 839090, 2022.
Article in English | MEDLINE | ID: covidwho-1753365
ABSTRACT

Background:

Myocarditis has been reported following the first two doses of Pfizer-BNT162b2 messenger RNA (mRNA) COVID-19 vaccination. Administration of a third dose (booster) of the vaccine was initiated recently in Israel.

Objective:

The aim of this study was to describe the characteristics of patients referred for cardiac magnetic resonance (CMR) imaging with myocarditis following the booster.

Methods:

Patients referred for CMR imaging with a clinical diagnosis of myocarditis within 21 days following the booster, between July 13 and November 11, 2021, were analyzed.

Results:

Overall, 4 patients were included, 3/4 (75%) were men, and the mean age was 27 ± 10 years. The time from booster administration to the onset of symptoms was 5.75 ± 4.8 days (range 2-14). Obstructive coronary artery disease was excluded in 3 of the patients (75%). CMR was performed 34 ± 15 days (range 8-47 days) following the 3rd vaccination. The mean left ventricular ejection fraction was 61 ± 7% (range 53-71%), and regional wall motion abnormalities were present in one of the patients. Global T1 was increased in one of the patients, while focal T1 values were increased in 3 of the patients. Global T2 was increased in one of the patients, while focal T2 values were increased in all the patients. Global ECV was increased in 3 of the patients, while focal ECV was increased in all the patients. Median late gadolinium enhancement (LGE) was 4 ± 3% (range 1-9%), with the inferolateral segment as the most common location (3 of the 4 patients). All the patients met the Updated Lake Louise Criteria.

Conclusions:

Patient characteristics and CMR imaging findings of myocarditis following the administration of the booster vaccine are relatively mild and consistent with those observed with the first two doses. Although larger-scale prospective studies are necessary, these initial findings are somewhat reassuring.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study Topics: Long Covid / Vaccines Language: English Journal: Front Cardiovasc Med Year: 2022 Document Type: Article Affiliation country: Fcvm.2022.839090

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study Topics: Long Covid / Vaccines Language: English Journal: Front Cardiovasc Med Year: 2022 Document Type: Article Affiliation country: Fcvm.2022.839090