Understanding the Effects of Age and T-Cell Differentiation on COVID-19 Severity: Implicating a Fas/FasL-mediated Feed-Forward Controller of T-Cell Differentiation.

Leonardi, Anthony J; Argyropoulos, Christos P; Hamdy, Adam; Proenca, Rui B

Leonardi, Anthony J; Argyropoulos, Christos P; Hamdy, Adam; Proenca, Rui B.

Leonardi AJ; Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
Argyropoulos CP; Department of Internal Medicine, Division of Nephrology, University of New Mexico School of Medicine, Albuquerque, NM, United States.
Hamdy A; Independent Researcher, Port Louis, Mauritius.
Proenca RB; Department of Biology, Johns Hopkins University, Baltimore, MD, United States.

Front Immunol ; 13: 853606, 2022.

Article in English | MEDLINE | ID: covidwho-1753373

Subject(s)

Aging/physiology; COVID-19/immunology; SARS-CoV-2/physiology; T-Lymphocytes/immunology; Age Factors; Cell Differentiation; Fas Ligand Protein/metabolism; Feedback, Physiological; Humans; Models, Biological; Severity of Illness Index; fas Receptor/metabolism

Keywords

CD8; Fas; FasL; SARS-CoV-2; T cells; differentiation; feed-forward Loop; paracrine

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Aging / T-Lymphocytes / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Prognostic study Limits: Humans Language: English Journal: Front Immunol Year: 2022 Document Type: Article Affiliation country: Fimmu.2022.853606

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