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Emergence of Progressive Mutations in SARS-CoV-2 From a Hematologic Patient With Prolonged Viral Replication.
Garcia-Vidal, Carolina; Iglesias-Caballero, María; Puerta-Alcalde, Pedro; Mas, Vicente; Cuesta-Chasco, Genoveva; Garcia-Pouton, Nicole; Varona, Sarai; Pozo, Francisco; Vázquez-Morón, Sonia; Marcos, Maria Angeles; Soriano, Alex; Casas, Inmaculada.
  • Garcia-Vidal C; Department of Infectious Diseases, Hospital Clinic of Barcelona-IDIBAPS, University of Barcelona, Barcelona, Spain.
  • Iglesias-Caballero M; Respiratory Virus and Influenza Unit, National Center of Microbiology, National Influenza Center, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
  • Puerta-Alcalde P; Department of Infectious Diseases, Hospital Clinic of Barcelona-IDIBAPS, University of Barcelona, Barcelona, Spain.
  • Mas V; Respiratory Virus and Influenza Unit, National Center of Microbiology, National Influenza Center, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
  • Cuesta-Chasco G; Department of Microbiology, ISGlobal, Hospital Clinic-Universitat de Barcelona, Barcelona, Spain.
  • Garcia-Pouton N; Department of Infectious Diseases, Hospital Clinic of Barcelona-IDIBAPS, University of Barcelona, Barcelona, Spain.
  • Varona S; Bioinformatics Unit, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
  • Pozo F; Respiratory Virus and Influenza Unit, National Center of Microbiology, National Influenza Center, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
  • Vázquez-Morón S; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
  • Marcos MA; Respiratory Virus and Influenza Unit, National Center of Microbiology, National Influenza Center, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
  • Soriano A; Department of Microbiology, ISGlobal, Hospital Clinic-Universitat de Barcelona, Barcelona, Spain.
  • Casas I; Department of Infectious Diseases, Hospital Clinic of Barcelona-IDIBAPS, University of Barcelona, Barcelona, Spain.
Front Microbiol ; 13: 826883, 2022.
Article in English | MEDLINE | ID: covidwho-1753389
ABSTRACT
We documented a hematologic patient with prolonged SARS-CoV-2 viral replication in whom emergence of viral mutations was documented after the consecutive use of antivirals and convalescent plasma. The virus detected in the last of 12 clinical samples (day 237) had accumulated 22 changes in amino acids and 29 in nucleotides. Some of these changes, such as the E484Q, were mutations of concern as defined by WHO. This finding represents an enormous epidemiological threat and poses a major clinical challenge. Combined antiviral strategies, as well as specific strategies related to the diagnostic approach of prolonged infections for this specific population, may be needed.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Front Microbiol Year: 2022 Document Type: Article Affiliation country: Fmicb.2022.826883

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Front Microbiol Year: 2022 Document Type: Article Affiliation country: Fmicb.2022.826883