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Local Anesthetics and Recurrence after Cancer Surgery-What's New? A Narrative Review.
Müller, Sarah D; Ziegler, Jonathan S H; Piegeler, Tobias.
  • Müller SD; Department of Anesthesiology and Intensive Care, University Hospital Leipzig, Liebigstrasse 20, 04103 Leipzig, Germany.
  • Ziegler JSH; Department of Anesthesiology and Intensive Care, University Hospital Leipzig, Liebigstrasse 20, 04103 Leipzig, Germany.
  • Piegeler T; Department of Anesthesiology and Intensive Care, University Hospital Leipzig, Liebigstrasse 20, 04103 Leipzig, Germany.
J Clin Med ; 10(4)2021 Feb 11.
Article in English | MEDLINE | ID: covidwho-1753571
ABSTRACT
The perioperative use of regional anesthesia and local anesthetics is part of almost every anesthesiologist's daily clinical practice. Retrospective analyses and results from experimental studies pointed towards a potential beneficial effect of the local anesthetics regarding outcome-i.e., overall and/or recurrence-free survival-in patients undergoing cancer surgery. The perioperative period, where the anesthesiologist is responsible for the patients, might be crucial for the further course of the disease, as circulating tumor cells (shed from the primary tumor into the patient's bloodstream) might form new micro-metastases independent of complete tumor removal. Due to their strong anti-inflammatory properties, local anesthetics might have a certain impact on these circulating tumor cells, either via direct or indirect measures, for example via blunting the inflammatory stress response as induced by the surgical stimulus. This narrative review highlights the foundation of these principles, features recent experimental and clinical data and provides an outlook regarding current and potential future research activities.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study / Reviews Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10040719

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study / Reviews Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10040719