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Detection of serum cytokines IL-6, IL-10 and IFN-P in COVID-19 patients as disease severity predictors
Biochemical and Cellular Archives ; 21(2):4005-4012, 2021.
Article in English | GIM | ID: covidwho-1755479
ABSTRACT
As of January, 2021, nearly 2-million deaths worldwide have been attributed to COVID-19, which is caused by SARS-CoV-2. Much of the mortality has been associated with a cytokine storm syndrome in patients admitted to hospital with COVID-19 pneumonia. The aims of this study are to estimate the severity of disease among patients from COVID-19 units in Diyala province and to estimate serum cytokines levels of interleukin-10, Interleukine-6 and Interferon gamma among studied patient groups. The data accumulated throughout this selective case control study which were extended from September 1st, 2020, to December 1st, 2020. A total of 176 human serum samples were collected, and subdivided into four groups moderate, sever, critical and control, each group comprised of 44 individuals. Analysis of data was carried out using the available statistical package of SPSS-20 (Statistical Packages for Social Sciences- version 20). The results revealed that the rate of infection with COVID-19 is higher in male (65.1%) than female (34.8%). The result of cytokines showed highly significant increase in the mean of interleukin-10 and interferon gamma and significant increase in interlukin-6 in patients with Covid-19 when compared to the control group, p-value = 0,000, p-value = 0.003, p-value = 0.016, respectively. The comparison of cytokine results among Covid-19 patients revealed that the Interleukin-10 showed significant increase in critical group when compared with moderate group p-value = 0.041, but don't showed any significant differences when compared the sever group with critical, and moderate groups p-value = 0.643 and p-value = 0.114, respectively. Interleukin-6 showed highly significant differences it is increased in critical group compared with moderate group and also increase compared to in severe group pvalue = 0.003, p-value = 0.013, respectively. While interleukin-6 showed no significant differences between severe and moderate groups p-value = 0.616. Interferon gamma showed no significant differences among moderate, severe and critical groups p-value = 0.527, p-value = 895, p-value = 447, respectively. In conclusions, there's a significant association in disease severity and elevated of circulating levels of cytokines Interleukine-10 and Interleukine-6, the rate of infection with COVID-19 is higher in male than female.
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Collection: Databases of international organizations Database: GIM Type of study: Prognostic study Language: English Journal: Biochemical and Cellular Archives Year: 2021 Document Type: Article

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Collection: Databases of international organizations Database: GIM Type of study: Prognostic study Language: English Journal: Biochemical and Cellular Archives Year: 2021 Document Type: Article