Cost-effectiveness analysis of BNT162b2 COVID-19 booster vaccination in the United States
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
; 2022.
Article
in English
| EuropePMC | ID: covidwho-1755869
ABSTRACT
Objectives:
To evaluate the cost-effectiveness of a booster strategy in the US.Methods:
We developed a decision-analytic Markov model of COVID-19 to evaluate the cost-effectiveness of a booster strategy of Pfizer-BioNTech BNT162b2 (administered 6 months after 2nd dose) among older adults, from a healthcare system perspective.Results:
Compared with 2-doses of BNT162b2 without a booster, the booster strategy in a 100,000 cohort of older adults would incur an additional cost of $3.4 million in vaccination cost, but save $6.7 million in direct medical cost and gain 3.7 QALYs in 180 days. This corresponds to a benefit-cost ratio of 1.95 and a net monetary benefit of $3.4 million. Probabilistic sensitivity analysis indicates that a booster strategy has a high chance (67%) of being cost-effective. Notably, the cost-effectiveness of the booster strategy is highly sensitive to the population incidence of COVID-19, with a cost-effectiveness threshold of 8.1/100,000 person-day. If vaccine efficacies reduce by 10%, 30%, and 50%, this threshold will increase to 9.7/100,000, 13.9/100,000, and 21.9/100,000 person-day, respectively.Conclusion:
Offering BNT162b2 booster to older adults aged ≥65 years in the US is likely to be cost-effective. Less efficacious vaccines and boosters may still be cost-effective in settings of high SARS-COV-2 transmission.
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Collection:
Databases of international organizations
Database:
EuropePMC
Type of study:
Experimental Studies
Topics:
Vaccines
Language:
English
Journal:
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Year:
2022
Document Type:
Article
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